ArticleCNS neuroscience & therapeutics2025
Perfusion and Structural Impairment in Minor Stroke and Transient Ischemic Attack With Intracranial Atherosclerotic Stenosis: Associations With Cognitive Decline.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Perfusion and Structural Impairment in Minor Stroke and Transient Ischemic Attack With Intracranial Atherosclerotic Stenosis: Associations With Cognitive Decline.CNS neuroscience & therapeutics · 2025Article
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Authors and funding
17 authors.
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Abstract
aimsTo investigate the characteristics of hypoperfusion and structural impairment in patients with transient ischemic attack (TIA) or minor stroke (MS) with intracranial atherosclerotic stenosis (ICAS) and evaluate its impact on cognitive decline.
methodsCognitive function in 47 patients and 33 health controls (HC) was assessed using the Montreal Cognitive Assessment (MoCA) tool. Arterial spin labeling with two distinct postlabeling delays and 3D T1 imaging was conducted to assess cerebral blood flow (CBF), morphometric features, and asymmetry index (AI).
resultsCompared with HC, both the left and right involved patients showed reduced scores for total MoCA score. Comparisons of CBF with HC revealed that significant ischemic areas in patients were primarily localized to the perfusion territory of the middle cerebral artery in the affected hemisphere (p < 0.05, family-wise error [FWE] corrected). Despite morphometry abnormality being locally confined, AI exhibits more widespread alterations across a wider range of brain regions (both p < 0.05, FWE corrected). Both hypoperfusion and structural impairment were significantly associated with reduced MoCA score in left-involved patients, whereas only hypoperfusion showed a significant association in those with right-hemisphere involvement (p < 0.05, FWE corrected). Furthermore, the effect of ischemia on cognition was mediated by structural impairment and compensatory CBF simultaneously.
conclusionThese findings highlight that hypoperfusion and structural impairment are already concerning and jointly associated with cognitive impairment in MS/TIA patients with ICAS, emphasizing the need for early detection and intervention.
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