Evidence map›Paper›PMID 41367239›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Identification of novel PTP1B inhibitor for the treatment of LPS-induced myocardial apoptosis: machine learning based virtual screening and biological evaluation.

Xu Dong, Bing Shang, Xin Li, Jie Zhang, Zhen Liu, Bo Feng

Abstract read
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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xu DongDepartment of Pharmacy, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Bing ShangDepartment of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xin LiState Key Laboratories of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.
Jie ZhangInstitute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhen LiuDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Bo FengDepartment of Pharmacy, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis-induced cardiovascular dysfunction (SICD) poses a serious threat to human life. Protein tyrosine phosphatase 1B (PTP1B) displays an essential role in SICD occurrence, so discovering novel inhibitors targeting PTP1B is an effective strategy for SICD treatment. In this research, we exploited a novel virtual screening pipeline consisting of both ligand-based and structure-based modules to find novel PTP1B inhibitors, and compound PI-2 with IC

Indexed as

ApoptosisEnzyme InhibitorsMachine LearningProtein Tyrosine Phosphatase, Non-Receptor Type 1AnimalsDose-Response Relationship, DrugDrug Evaluation, PreclinicalHumansLipopolysaccharidesMolecular StructureStructure-Activity RelationshipEnzyme InhibitorsLipopolysaccharidesProtein Tyrosine Phosphatase, Non-Receptor Type 1PTPN1 protein, humanPTP1B inhibitorsepsis induced cardiovascular dysfunctionvirtual screening

Identifiers

PMID41367239
PMCPMC12697290

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.