ArticleTranslational pediatrics2025
Determinants of intertransfusion interval in children with transfusion-dependent thalassemia: a retrospective single-center cohort study in China.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Balancing statistical rigor and clinical applicability in transfusion research on transfusion-dependent thalassemia: a clarification.Translational pediatrics · 2026Article
- Factors influencing intertransfusion interval in children with transfusion dependent thalassemia.Translational pediatrics · 2026Article
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7 authors.
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Abstract
Background: Optimizing transfusion regimens is crucial for children with transfusion-dependent thalassemia (TDT). This study aimed to identify the determinants of intertransfusion intervals to address this need. Methods: This single-center retrospective observational study included 21 pediatric β-thalassemia patients with 392 transfusions. Transfusions were grouped by median interval (18 days). The associations between intertransfusion intervals and demographics, genotype, red blood cells (RBC) product characteristics, as well as transfusion adequacy were analyzed using univariate tests and correlation analysis. Binary logistic regression was used to identify the independent determinants of intertransfusion intervals, and then multivariable linear regression was constructed to evaluate the factors influencing hemoglobin levels before the subsequent transfusion. Results: Genotype severity [major Conclusions: Genotype severity and RBC product type significantly affect intertransfusion intervals in pediatric TDT. Personalized strategies considering these factors may optimize transfusion efficacy and reduce complications.
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