ArticleTranslational pediatrics2025
Development of a nomogram for predicting refractory
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Refractory Methods: This prospective study enrolled children diagnosed with Results: A total of 210 children were included, among whom 105 were diagnosed with RMPP. The median age was 7.0 years (interquartile range, 5.0-8.5 years), and 42.4% of participants were male. No significant differences in age or sex were observed between groups (P<0.05). Multivariate analysis identified fever duration [odds ratio (OR) =2.15, P<0.001], duration of glucocorticoid use (OR =1.56, P<0.001), and YKL-40 levels (OR =1.01, P=0.001) as independent risk factors for RMPP. The nomogram incorporating these three factors demonstrated excellent discrimination with an AUC of 0.92 (95% confidence interval: 0.88-0.96). Calibration curve and Hosmer-Lemeshow test (P>0.99) indicated excellent calibration. DCA confirmed the clinical utility of the nomogram, showing net benefit across a wide threshold probability range (0.04-0.94). Conclusions: The nomogram constructed based on fever duration, glucocorticoid use duration, and YKL-40 level shows promise for early prediction of RMPP in children.
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