ArticleQuantitative imaging in medicine and surgery2025
Ultrasound molecular imaging in evaluating the severity of ischemia-reperfusion injury-induced acute kidney injury.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ultrasound-Triggered Nanobubbles for Endothelial-Targeted Drug Delivery in the Detection and Treatment of Doxorubicin-Induced Cardiotoxicity.Advanced healthcare materials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute kidney injury (AKI) is a global public health issue for which the prognosis varies, depending on the severity. Early and accurate assessment of the severity of AKI is crucial for determining the prognosis of patients. Ultrasound molecular imaging (USMI) technology can be used to evaluate AKI, but studies on assessing the inflammatory responses of different severity levels of AKI have not been reported. Therefore, this study aimed to explore the early value of USMI technology based on vascular cell adhesion molecule-1 (VCAM-1) targeted microbubbles in monitoring the severity of AKI at the molecular level. Methods: A total of 66 mice were randomly divided into a mild ischemia-reperfusion injury (IRI)-AKI (m-AKI) group, severe IRI-AKI (s-AKI) group, and sham operation group (sham group). USMI was used to monitor renal inflammatory responses to different injury levels in AKI. Pearson's correlation was used to analyze the correlation between USMI and pro-inflammatory factors and VCAM-1 protein expression. Receiver operating characteristic (ROC) curves were drawn to investigate the efficacy in diagnosing mild and severe AKI at different reperfusion time points. Results: The normalized intensity difference (NID) at different reperfusion time points (0.5, 2, 6, 12, and 24 h) in the s-AKI group was higher than that in the m-AKI group (P<0.05). NID was positively correlated with VCAM-1 protein expression, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) levels (r=0.852, 0.794, and 0.748, respectively, all P<0.05). The NID had good diagnostic efficacy in diagnosing the degree of injury in AKI at various reperfusion time points. The area under the ROC curve (AUC) of NID was 0.895 [95% confidence interval (CI): 0.813-0.977], which is superior to serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C (Cys-C), kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) (P<0.05). Conclusions: USMI can be used in the early assessment of the renal inflammatory response of different degrees of AKI, which is superior to commonly used renal function assessment indicators and early biomarkers. USMI may provide helpful information for the diagnosis and assessment of the severity of AKI.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.