ArticleQuantitative imaging in medicine and surgery2025
Preoperative risk stratification of colorectal high-grade intraepithelial neoplasia based on endoscopic biopsy: superior performance of
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High-grade intraepithelial neoplasia (HGIN) is the stage at which high-grade dysplasia is present but there is no invasion beyond the muscularis. Endoscopic forceps biopsy (EFB) is the gold standard for the histological diagnosis of colorectal epithelial neoplasia. However, histopathologic discrepancy exists between EFB and postresection specimens. This study aimed to compare the diagnostic accuracy and clinical utility of positron emission tomography-computed tomography (PET/CT) with those of contrast-enhanced computed tomography (CECT) in optimizing the preoperative decision-making for surgical intervention in patients with HGIN diagnosed endoscopically. Methods: The study examined 83 lesions, 30 of which underwent both PET/CT and CECT imaging. Demographic data, endoscopic characteristics of lesions, imaging assessments (PET/CT and CECT), and histopathological results were systematically analyzed. Receiver operating characteristic (ROC) curves were analyzed to determine the efficacy of PET/CT and CECT in distinguishing primary lesions and metastases in lymph nodes, the liver, omentum, and bone. The risk factors for the pathological escalation of HGIN were analyzed. Results: The percentage of HGINs upgraded to invasive colorectal cancer (CRC) as confirmed by postoperative pathology was 69.8% (58/83). PET/CT had higher sensitivity, positive predictive value (PPV), and negative predictive value (NPV) for primary lesions and metastasis than did CECT. PET/CT had significantly higher area under curve (AUC) values for primary lesions, lymph nodes, and peritoneal metastases than did CECT (P<0.05). Surface rupture and maximum size >2 cm were independent risk factors for pathologic escalation of HGINs, whereas the presence of pedunculated lesions was a protective factor. Conclusions: Invasive CRC is at a risk of being underdiagnosed as HGIN by EFB. PET/CT outperforms CECT in the preoperative staging of EFB-diagnosed HGIN. Further, when endoscopic lesions present with a diameter greater than 2 cm and superficial ulceration, PET/CT examination may be considered.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.