Evidence map›Paper›PMID 41367847›Full record

ArticleSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

Is serum angiotensin-converting enzyme a suitable biomarker for differentiating idiopathic and demyelinating optic neuritis?

Alireza Dehghani, Nastaran-Sadat Hosseini, Majid Mirmohammadkhani, Matin Irajpour, Maryam Moayeri, Arman Amirkhani, Fatemeh Esfahanian, Mohsen Pourazizi

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Article in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Alireza DehghaniDepartment of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nastaran-Sadat HosseiniStudent Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Majid MirmohammadkhaniDepartment of Epidemiology and Biostatistics, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Matin IrajpourDepartment of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam MoayeriDepartment of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Arman AmirkhaniDepartment of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh EsfahanianStudent Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohsen PouraziziDepartment of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of the study was to measure serum angiotensin-converting enzyme (ACE) in patients diagnosed with idiopathic and demyelinating optic neuritis (ON) as well as heathy individuals and assess its viability as a biomarker.

methodsThis clinical case-control study was conducted on patients diagnosed with acute ON as the case group and healthy controls aged between 18 and 50 years. Based on findings from systemic and neurological evaluation, the study group was divided into: Idiopathic ON and demyelinating ON (including multiple sclerosis [MS], neuromyelitis optica [NMO], and clinically isolated syndrome [CIS]) subgroups. Serum ACE levels were measured using enzyme-linked immunosorbent assay and compared between groups.

resultsFifty-one patients with acute ON (78.4% female, mean age 29.8 ± 8.4 years) and 51 controls (78.4% female, mean age 29.9 ± 6.9 years) were enrolled in this study. In the case group, 29 patients were diagnosed with idiopathic ON (56.9%), and 22 patients with demyelinating types of ON (43.1%) (MS-ON,

conclusionOur findings did not exhibit a significant difference in terms of serum ACE level between patients diagnosed with idiopathic ON and demyelinating ON. However, serum ACE level in both groups is significantly higher compared to healthy subjects.

Indexed as

Angiotensin-converting enzymemultiple sclerosisneuromyelitis opticaoptic neuritis

Identifiers

PMID41367847
PMCPMC12685261

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.