Evidence map›Paper›PMID 41367971›Full record

ArticleJAACAP open2025

The Impact of Polygenic Risk, Parental Separation, and Parental Relationship Discord on Heavy Episodic Drinking Across Adolescence and Young Adulthood in a High-Risk Sample.

Sally I-Chun Kuo, Vivia V McCutcheon, Kathleen K Bucholz, Danielle M Dick, Fazil Aliev, Jacquelyn L Meyers, Sarah J Brislin, Grace Chan, Howard J Edenberg, Chella Kamarajan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAACAP open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sally I-Chun KuoRobert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.
Vivia V McCutcheonWashington University School of Medicine, St. Louis, Missouri.
Kathleen K BucholzWashington University School of Medicine, St. Louis, Missouri.
Danielle M DickRobert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.
Fazil AlievRobert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.
Jacquelyn L MeyersSUNY Downstate Health Sciences University, Brooklyn, New York.
Sarah J BrislinRobert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.
Grace ChanUniversity of Connecticut School of Medicine, Farmington, Connecticut.
Howard J EdenbergIndiana University School of Medicine, Indianapolis, Indiana.
Chella KamarajanSUNY Downstate Health Sciences University, Brooklyn, New York.
John KramerUniversity of Iowa Carver College of Medicine, Iowa City, Iowa.
Samuel KupermanUniversity of Iowa Carver College of Medicine, Iowa City, Iowa.
Dongbing LaiIndiana University School of Medicine, Indianapolis, Indiana.
Martin H PlaweckiIndiana University School of Medicine, Indianapolis, Indiana.
Carolyn E SartorRobert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.
Marc A SchuckitUniversity of California San Diego School of Medicine, La Jolla, California.
Jessica E SalvatoreRobert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Translational genetic analysis in human and mouse GWAS to identify the genomic architecture of alcohol sensitivity and toleranceR01AA031176 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI Dongbing Lai, Yunlong Liu · 2024 to 2026
$1.6M
Using genetically informed designs to understand the impact of parental divorce/separation and parental marital discord on offspring alcohol outcomesR01AA028064 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2020 to 2023
$1.3M
NIAAA NIH HHS R01 AA028064NIAAA NIH HHS R01 AA031176NIAAA NIH HHS U10 AA008401
6 · The paper itself

Abstract

Objective: Parental separation and relationship discord are linked to alcohol use behaviors, but their influence on the longitudinal course of alcohol misuse and interactions with genetic predisposition remain unclear. This study examined how the longitudinal course of heavy episodic drinking (HED) from adolescence to young adulthood varies with polygenic risk, parental separation, and relationship discord. Method: Participants were from the Collaborative Study on the Genetics of Alcoholism (COGA) Prospective Sample, and included individuals from 2 genetically inferred continental groups: European-like (EA; n = 1761) and African-like (AA; n = 894) who were reassessed biennially (mean age = 16.39 at first assessment; mean assessments = 4.65). Alcohol misuse was indexed by past-year HED frequency. Predictors included parental separation, parental relationship discord, and problematic alcohol use polygenic scores (PGS Results: HED increased through young adulthood before declining. In European Americans (EA), parental separation was associated with HED intercepts, but not with linear slope or quadratic curvature. Higher PGS Conclusion: Genetic risk and exposure to parental separation and discord are associated with the course of HED, with some differences across continental groups.

Indexed as

heavy episodic drinkingparental conflictparental divorcepolygenic scorestrajectories

Identifiers

PMID41367971
PMCPMC12684652

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.