Evidence map›Paper›PMID 41368108›Full record

ReviewWorld journal of hepatology2025

Genetic predeterminants and recent advancements in steatotic liver disease: A roadmap toward precision hepatology.

Ganesh Kumar, Yash R Shah, Abeer Shahzad, Khadija Jameel, David Guevara-Lazo, Najia Ali Khan, Dushyant Singh Dahiya, Manesh Kumar Gangwani, Rakshana Ravichandran, Ravi Patel and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ganesh KumarDepartment of Internal Medicine, Chandka Medical College, Sindh 77170, Pakistan.
Yash R ShahDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. yashu211996@gmail.com.
Abeer ShahzadDepartment of Internal Medicine, Dow Medical College, Karachi 74200, Sindh, Pakistan.
Khadija JameelDepartment of Internal Medicine, Dow Medical College, Karachi 74200, Sindh, Pakistan.
David Guevara-LazoFaculty of Medicine, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Najia Ali KhanDepartment of Internal Medicine, Khyber Medical College, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan.
Dushyant Singh DahiyaDivision of Gastroenterology, Hepatology, and Motility, University of Kansas Medical Center, Kansas, KS 66160, United States.
Manesh Kumar GangwaniDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Rakshana RavichandranDepartment of Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, MI 48341, United States.
Ravi PatelDepartment of Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, MI 48341, United States.
Umar HayatDepartment of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkes Barre, PA 18711, United States.
Ragesh B ThandasseryDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steatotic liver disease (SLD) encompasses a group of disorders characterized by the excessive accumulation of fat in the liver. It is classified into four categories based on clinical manifestations: Metabolic dysfunction-associated SLD (MASLD), metabolic-alcohol-associated liver disease (ALD), ALD, and cryptogenic SLD. In the United States, its prevalence stands at 34.2%, making it the most common cause of cirrhosis and hepatocellular carcinoma (HCC). In addition to factors related to endocrine, nutrition, and medications, several genetic markers have been implicated in the disease's pathogenesis. Notable genes include

Indexed as

GCKRHepatocellular carcinomaHSD17B14MBOAT7Metabolic dysfunction-associated steatotic liver diseasePNPLA3Steatotic liver diseaseTM6SF2

Identifiers

PMID41368108
PMCPMC12683380

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.