ReviewInternational journal of nanomedicine2025
Muco-Adhesive Hydrogels-Based Exosome Delivery for Periodontal Tissue Regeneration and Inflammation Reduction: A Review.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Regenerative Surgery, State of the Art and New Perspectives: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review highlights the potential of muco-adhesive hydrogel-based exosome delivery vehicles for the regeneration of periodontal tissue and the reduction of inflammation in periodontitis. Exosomes, mainly produced from mesenchymal stem cells (MSCs), represent nano-sized vesicles loaded with bioactive molecules that can stimulate tissue repair and modulate inflammatory pathways. The review provides a thorough view for the synthesis of the in vitro, in vivo and clinical-pilot studies on exosome-loaded muco-adhesive hydrogels, encompassing the physicochemical characterization, exosome delivery and biological efficacies. In vitro studies highlight the regenerative potential of exosomes on periodontal ligament cells and on alveolar bone cells. In vivo animal models have shown significant improvements in tissue regeneration with effective inflammation control. Preliminary clinical pilot studies similarly show promising results for periodontal tissue healing. The use of exons in combination with muco-adhesive hydrogels provides an effective and non-invasive approach for the targeted, prolonged therapeutic delivery for the treatment of periodontal disease. The main conclusion of this review is that exosome loaded muco-adhesive hydrogels represent a promising strategy for developing strategies to treat periodontitis, setting up as its double aims to enhance the regeneration of tissues and reduce inflammation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.