Evidence map›Paper›PMID 41368325›Full record

ReviewBioactive materials2026

Engineered bacteria and bacteria-derived nanomaterials for cancer therapy: Mechanisms, designs and advances.

Qinzhen Cheng, Yalan Zhu, Shiwen Lv, Jiacheng Shi, Mingjie Kuang, Li Wang, Xiaoyuan Ji

Abstract readReview
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
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  7. Nanotechnology Meets Immunotherapy: Crosstalks Against Cancer.Immunity, inflammation and disease · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Optimization Strategies and Synergistic Applications of EngineeredInternational journal of nanomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qinzhen ChengDepartment of Pharmacy, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, 321000, China.
Yalan ZhuDepartment of Pharmacy, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, 321000, China.
Shiwen LvDepartment of Pharmacy, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, 321000, China.
Jiacheng ShiAcademy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China.
Mingjie KuangDepartment of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Li WangAcademy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China.
Xiaoyuan JiAcademy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria have emerged as powerful and versatile platforms for cancer therapy, leveraging their inherent tumor-targeting capabilities, adaptability to engineering, and ability to interact dynamically with the tumor microenvironment (TME). This review systematically introduces the multimodal mechanisms of action underlying bacteria-based cancer therapeutics, from direct tumor lysis to bacterial tropism and immune modulation in the TME. We summarize engineering strategies for bacteria-based cancer therapy through two principal approaches: biological engineering (genetic reprogramming and biofilm encapsulation) and physicochemical modification (chemical conjugation, physical interaction, and biomineralization coating). This discussion highlights the key applications of live bacteria, including facultative anaerobes (e.g.,

Indexed as

BacteriaBacterial derivativesCancer therapyEngineering strategyTumor microenvironment

Identifiers

PMID41368325
PMCPMC12684465

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.