ArticleFood science & nutrition2025
Exploring Molecular Targets of Quercetin for the Treatment of Nicotine-Related Oral Carcinoma: A Network Pharmacology Analysis and In Vitro Study.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Exploring Molecular Targets of Quercetin for the Treatment of Nicotine-Related Oral Carcinoma: A Network Pharmacology Analysis and In Vitro Study.Food science & nutrition · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotine, which is enriched in tobacco, has been identified as an important factor in the development of oral cancer. The natural flavonoid quercetin has potential anti-tumor properties due to its low toxicity and high efficacy. We aimed to explore the potential molecular targets of quercetin for the treatment of nicotine-related oral cancer by network pharmacological analysis and to evaluate its efficacy in vitro experiments. A total of 29 potential target genes were identified, which may be associated with epithelial-mesenchymal transition (EMT), the receptor tyrosine kinase (RTK) pathway, and immune cell infiltration, as well as acquired resistance to various chemotherapeutic agents. Molecular docking and molecular dynamics simulation indicated that quercetin may bind more strongly to potential key genes (THBS1, SERPINE1, and IGF1R). Quercetin was shown to affect key gene expressions in nicotine-related oral cancer cells and attenuate their malignant phenotype in vitro experiments. A series of novel targets for quercetin in the treatment of nicotine-related oral cancer were identified. These findings not only help understand the pathogenesis of oral cancer but also help explore its precancerous preventive measures, which are of great value for oral cancer prevention.
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