ReviewClinical, cosmetic and investigational dermatology2025
Antioxidative and Regenerative Potential of Sea Cucumber: Focus on Bioactive Compounds and Exosome-Based Strategies for Combating Skin Oxidative Stress.
Review in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Oxidoreductase Activity of a Stable Multi-protein Complex from the Sea Cucumber Eupentacta fraudatrix.The protein journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, has a profound effect on skin health. This imbalance contributes to skin damage, premature aging, and the development of various dermatological conditions by modulating key signaling pathways with pro-inflammatory or antioxidant effects, such as NF-κB, JAK/STAT, Nrf2, MAPK/AP1, and SIRT1/FOXO. So, the application of antioxidant compounds, particularly those derived from natural sources, is essential for protecting the skin against ROS-induced damage. Sea cucumber, a marine invertebrate known for its remarkable regenerative capacity, contains bioactive compounds, including phenolics, proteins, and polysaccharides, which exhibit antioxidative and anti-inflammatory properties. These bioactive components may offer protective effects against oxidative stress within the skin. Therefore, this study will first evaluate the potential of sea cucumber-derived bioactive compounds in mitigating oxidative stress by examining their ability to counteract ROS-induced cellular damage caused by ROS and their potential role in promoting skin repair and regeneration. The review will also discuss the underlying mechanisms, including key signaling pathways, and explore the therapeutic potential of sea cucumber-derived exosomes as a novel strategy to treating oxidative stress-related skin disorders. Finally, a comparison is made between the efficacy of the sea cucumber crud extract with its derived exosome in treating oxidative stress-induced skin damage.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.