Evidence map›Paper›PMID 41368581›Full record

ArticleFrontiers in pharmacology2025

Cannabis-based extract for managing pain in dogs with osteoarthritis: efficacy and safety assessment.

Neide Maria Griebeler, Ricardo Penayo Cremonese, Yasmin Rafaela Fakih Correa, Priscila Romero Mazzini Pereira, Amanda Furjan Rial, Emanuela Leite, Maria Victoria Luz Gonçalves, Luiz Renato Marques das Almas, Nedice Borges Cardoso, Fernando Cezar-Dos-Santos and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Neide Maria Griebeler *Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Ricardo Penayo Cremonese *Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Yasmin Rafaela Fakih CorreaLaboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Priscila Romero Mazzini PereiraLaboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Amanda Furjan RialPOP-VET Veterinary Hospital, Foz do Iguaçu, Brazil.
Emanuela LeiteLaboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Maria Victoria Luz GonçalvesLaboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Luiz Renato Marques das AlmasAssociação Santa Cannabis, Florianópolis, Brazil.
Nedice Borges CardosoEnvironmental and Food Interdisciplinary Studies Laboratory - LEIMAA, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Fernando Cezar-Dos-SantosLaboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Aline Theodoro TociEnvironmental and Food Interdisciplinary Studies Laboratory - LEIMAA, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Andrés Mojoli Le-QuesneLaboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.
Francisney Pinto NascimentoLaboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integração Latino Americana (UNILA), Foz do Iguaçu, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Canine osteoarthritis (OA) is a prevalent disease characterized by progressive joint degeneration, pain, and impaired mobility. In older dogs, OA affects approximately 80% of the population. Current pharmacological treatments are often limited in efficacy and may cause significant adverse effects. In this context, cannabinoids have emerged as a promising therapeutic alternative. Methods: This double-blind, randomized study aimed to evaluate the efficacy and safety of a full-spectrum cannabis extract in managing OA-related pain and dysfunction in dogs. Seventeen dogs with OA were randomly assigned to receive either the cannabis extract (containing measured amounts of CBD, THC, CBG, CBC, and other cannabinoids) or a placebo for 90 days. Results: Although the cannabis treatment did not significantly reduce pain levels according to the Helsinki Chronic Pain Index (HCPI) [F(1,14) = 0.001, p = 0.981, η Conclusion: Our findings suggest that full-spectrum cannabis extract containing CBD and THC is safe for use in dogs for up to 90 days. However, further research is needed to determine the optimal doses and formulations required to effectively alleviate OA-induced pain.

Indexed as

adverse eventscaninecannabinoidsefficacyosteoarthritisquality of lifesafety

Identifiers

PMID41368581
PMCPMC12682811

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.