ArticleInternational journal of women's health2025
Study on Bone Mineral Density Around the Knee in Postmenopausal Women with Osteoarthritis and Osteoporosis.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanistic Links Underlying the Comorbidity of Osteoporosis and Osteoarthritis: Cell Fate Plasticity Driven by the Subchondral Bone Microenvironment.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoporosis (OP) and knee osteoarthritis (KOA) are common comorbidities in postmenopausal women, yet the relationship between OP and localized bone mineral density (BMD) around the knee remains unclear. This study investigated the effect of concomitant OP on periarticular BMD and its associations with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), radiographic severity, and hip-knee-ankle (HKA) angle in postmenopausal women with KOA. Methods: In this cross-sectional study, 117 postmenopausal women were classified into a KOA combined with OP group (n=59) and a KOA-only group (n=58) based on dual-energy X-ray absorptiometry (DXA) T-scores. All participants underwent dual-energy computed tomography (DECT) to quantify BMD around the distal femur, proximal tibia, and patella; weight-bearing radiographs to assess Kellgren-Lawrence (K&L) grade and HKA angle; and the WOMAC questionnaire to evaluate pain and joint function. Results: Patients with KOA combined with OP demonstrated significantly lower knee BMD than those with KOA alone (P < 0.001). This reduction in BMD was more pronounced with increasing OP severity. Notably, even after adjusting for pain levels, BMD remained significantly lower in the KOA combined with OP group (P < 0.05). Furthermore, medial knee BMD in the KOA combined with OP group exhibited an inverted U-shaped relationship with K&L grade, peaking at grade III before declining. In contrast, BMD increased progressively with K&L grade in the KOA group. A significant inverse correlation was also observed between the HKA angle and medial knee BMD in the KOA combined with OP group, suggesting greater bone loss with increasing valgus deformity. Conclusion: Postmenopausal women with KOA combined with OP have markedly lower periarticular BMD, associated with more severe pain, distinctive radiographic changes, and poorer alignment. These findings highlight the need for active bone preservation and OP management in KOA patients to alleviate symptoms and potentially slow disease progression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.