Evidence map›Paper›PMID 41368689›Full record

ReviewFEBS open bio2026

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications.

Anđela Pustak, Aleksandra Maršavelski

Abstract readReview
In one paragraph

Review in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. How PLGA Microspheres are Emerging as a Key Drug Delivery System.International journal of nanomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anđela PustakRadiation Chemistry and Dosimetry Laboratory, Division of Materials Chemistry, Ruđer Bošković Institute, Zagreb, Croatia.
Aleksandra MaršavelskiDepartment of Chemistry, Faculty of Science, University of Zagreb, Croatia.ORCID https://orcid.org/0000-0003-1139-7173

Funding

Development Research Support (NextGenerationEU) for the project Enzyme Engineering for sustainable recycling of bioplastics NPOO.C3.2.R2-I1.06.0041
6 · The paper itself

Abstract

Plastic waste from fossil-derived polymers remains a major environmental challenge, driving interest in biopolymers and enzyme-enabled end-of-life strategies. This review synthesizes current understanding of how polymer structure and thermal state govern enzymatic degradability, with emphasis on semicrystalline architectures and state-dependent accessibility. Within the Keller-Flory two-phase framework, crystalline lamellae embedded in an amorphous matrix dictate water/enzyme diffusion, chain mobility, and hydrolysis kinetics. Enzymatic attack preferentially initiates in amorphous regions, producing characteristic biphasic behavior as amorphous domains erode faster than crystalline regions, leading to crystallinity enrichment and subsequent slowing of degradation. Thermal transitions further modulate this balance: near or above T

Indexed as

EnzymesBiopolymersHydrolysisBiopolymersEnzymesamorphous statebiopolymersenzyme‐catalyzed degradationmolten statepolymer crystallinitythermal transitions

Identifiers

PMID41368689
PMCPMC13042798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.