ArticleCirculation. Cardiovascular imaging2026
Molecular MRI of Collagen Enables Evaluation of Fibrosis and Therapeutic Response in Venous Thrombosis.
Article in Circulation. Cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFibrosis, with accumulation of type I collagen, is a hallmark of postthrombotic change after deep vein thrombosis (DVT), but tools for its direct detection are lacking. Here, we investigate whether molecular magnetic resonance imaging (MRI) using a collagen-specific gadolinium-based probe can detect and measure changes in collagen during thrombus resolution and in response to treatment in a mouse model of DVT.
methodsVenous thrombus was induced in the inferior vena cava of BALB/c mice (n=45), and MRI was performed at day 2 (n=3) and weeks 1, 2, and 3 post-surgery using the collagen-specific probe, EP-3533 (10 μmol/kg; n=11-13/group). A subgroup of mice with DVT (n=7) was treated with pravastatin in drinking water (40 mg/kg per day) for 3 weeks post-DVT. Pre- and post-EP-3533 MRI scans were performed. Magnetic resonance venography was used to measure thrombus volume. Inversion recovery T1-weighted images and T1 maps, pre- and post-contrast, were used to calculate the percent change (%) in Δ contrast-to-noise ratio, Δ signal-to-noise ratio, and Δ relaxation rate. Tissues were used for ex vivo analyses.
resultsEP-3533 uptake increased during thrombus organization and resolution, resulting in MRI signal enhancement, with % Δ contrast-to-noise ratio, % Δ signal-to-noise ratio, and % Δ relaxation rate peaking at 3 weeks after DVT. MRI measurements of collagen accumulation quantified as an increase in % Δ contrast-to-noise ratio (ρ=0.89;
conclusionsMolecular MRI using a collagen-targeting probe made collagenous thrombus visible on MRI and detected changes in collagen content during thrombus resolution.
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