Evidence mapPaperPMID 41368779Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2025

A Preclinical Study on 4-Methyl-N-((4-(trifluoromethoxy)phenyl) carbamoyl)-benzenesulfonamide as a Potent Chemotherapeutic Agent against Liver and Pancreatic Carcinogenesis in Rats: Immunohistochemical and Histopathological Studies.

Farid M Sroor, Eman A Younis, Hanan F Aly

Abstract read
PubMed Publisher
In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Farid M SroorDepartment of Organometallic and Organometalloid Chemistry, National Research Centre, 12622 Cairo, Egypt.ORCID 0000-0003-1283-2157
Eman A YounisDepartment of Therapeutic Chemistry, National Research Centre, 12622 Cairo, Egypt.
Hanan F AlyDepartment of Therapeutic Chemistry, National Research Centre, 12622 Cairo, Egypt.

Funding

National Research Centre (NRC) 13020133
6 · The paper itself

Abstract

backgroundAlternative and complementary applications of newly synthesized chemicals have enhanced the prospect of finding curative treatments for hepatocarcinogenesis and pancreatic cancer.

methodsThe current study investigated the curative effect of the newly synthesized drug 4- methyl-N-((4-(trifluoromethoxy) phenyl) carbamoyl) benzenesulfonamide (3) against diethyl nitrosamine (DEN) (50 mg/kg) and carbon tetrachloride (CCl

resultsThe findings demonstrated that the DEN/CCl

conclusionThe new synthetic medication 3 could be an effective chemotherapeutic method for treating DEN and CCl

Indexed as

Antineoplastic AgentsCarcinoma, HepatocellularLiver NeoplasmsPancreatic NeoplasmsSulfonamidesAnimalsCarbon TetrachlorideCarcinogenesisDiethylnitrosamineImmunohistochemistryLiverMaleOxidative StressPancreasRatsRats, WistarAntineoplastic AgentsCarbon TetrachlorideDiethylnitrosamineSulfonamideschemotherapeutic agent.histopathological analysisimmunohistochemicalpancreatic carcinogenesisSulfonamidetrifluoromethyl

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.