ArticleJournal of the American Heart Association2025
Epigenetic Aging Clocks and Incident Cardiovascular Outcomes: Results From the MESA.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Transcriptomic landscape of human cardiac aging: identification of cardioselective age-associated genes and predictive modeling.Biogerontology · 2026Article
- Association of Type D Personality and Anatomical Complexity as Predictors of Long-Term Mortality in Coronary Artery Disease: A Retrospective Case Study Based on Hospital Records.Diseases (Basel, Switzerland) · 2026Article
- Global and regional DNA methylation patterns in heart failure: a case-control analysis.EBioMedicine · 2026Article
- Biological aging clocks in health and disease.Nature medicine · 2026Review
- Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study.Journal of the American Heart Association · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundDNA methylation-based aging clocks capture biological aging processes and may improve cardiovascular risk prognostication. However, evidence about epigenetic aging clocks, incident outcomes, and interactions with clinical biomarkers such as coronary artery calcium (CAC) in diverse cohorts are limited.
methodsIn this retrospective cohort study, we assessed 1264 MESA (Multi-Ethnic Study of Atherosclerosis) participants (mean age, 69 years; 49% men) who provided DNA at examination 5 (2010-2012). Epigenetic clock measures included GrimAge and age acceleration (the residual of GrimAge on chronological age). Outcomes included incident myocardial infarction, coronary heart disease, stroke, heart failure (HF) subtypes, and composite cardiovascular disease through 2019. Cox proportional hazards models adjusted for demographics, behaviors, comorbidities, and medications and stratified by CAC presence.
resultsDuring a median 8.3 years of follow-up, 223 cardiovascular disease, 76 myocardial infarction, 148 coronary heart disease, 21 stroke, and 109 HF events (49 HF with reduced ejection fraction, 14 HF with mildly reduced ejection fraction, 46 HF with preserved ejection fraction) occurred. In fully adjusted models, GrimAge was independently associated with higher risk of composite cardiovascular disease (hazard ratio [HR], 1.05 [95% CI, 1.02-1.08]), stroke (HR, 1.08 [95% CI, 1.04-1.13]), and HF with mildly reduced ejection fraction (HR, 1.31 [95% CI, 1.13-1.53]). Associations with myocardial infarction attenuated after full adjustment in those without baseline CAC but remained significant among those with baseline CAC >0 (myocardial infarction: HR, 1.09 [95% CI, 1.03-1.16]).
conclusionsAging clocks may capture cardiovascular risk beyond traditional risk factors and work in concert with subclinical disease measures such as CAC. However, given small numbers of stroke/HF subtypes, replication of these results in other populations is needed to assess whether interventions that slow epigenetic aging or target CAC translate into fewer clinical events.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.