Evidence map›Paper›PMID 41369256›Full record

ArticlemBio2025

Assessing the function of the alternative electron transport chain in the

Silu Deng, Wandy Beatty, L David Sibley

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Silu DengDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Wandy BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-7110-0285

Funding

Effect of Microbial Metabolites on Growth of CryptosporidiumR01AI145496 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2020 to 2023
$2.7M
Influence of microbial metabolites on mitosome function in CryptosporidiumR01AI192672 · NIAID · WASHINGTON UNIVERSITY · PI L. David Sibley · 2025 to 2026
$1.4M
NIAID NIH HHS R01 AI145496NIAID NIH HHS R01 AI192672
6 · The paper itself

Abstract

IMPORTANCE: Cryptosporidiosis is a leading cause of diarrhea in young children and immunocompromised individuals, particularly AIDS/HIV patients. The only FDA-approved drug against cryptosporidiosis, nitazoxanide, has limited effectiveness in immunocompromised patients and is not approved for use in children under 1 year. Genomic analysis and previous studies proposed an alternative respiration pathway involving alternative oxidase (AOX) and type II NAD(P)H dehydrogenase (NDH2), which are thought to generate the mitosome membrane potential in

Indexed as

Cryptosporidium parvumMitochondriaMitochondrial ProteinsNADH DehydrogenaseOxidoreductasesPlant ProteinsAlternative OxidaseElectron TransportGene Knockout TechniquesProtozoan ProteinsAlternative OxidaseMitochondrial ProteinsNADH DehydrogenaseNADH dehydrogenase IIOxidoreductasesPlant ProteinsProtozoan Proteinsalternative oxidasecryptosporidiosismitochondriatype II NADH dehydrogenase

Identifiers

PMID41369256
PMCPMC12691609

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.