Evidence map›Paper›PMID 41369721›Full record

ArticleMolecular biotechnology2026

Repurposing Ammi visnaga Furanocoumarins as Potent Squalene Epoxidase Inhibitors to Disrupt Lipid Metabolism: An Integrated Phytochemical, In Vitro, and In Silico Study.

Emadeldin M Kamel, Doaa A Abdelrheem, Fahad M Alshabrmi, Maha A Alwaili, Faris F Aba Alkhayl, Al Mokhtar Lamsabhi

Abstract read
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In one paragraph

Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emadeldin M KamelChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt. emad.abdelhameed@science.bsu.edu.eg.ORCID http://orcid.org/0000-0002-1279-9564
Doaa A AbdelrheemChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.
Fahad M AlshabrmiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 51452, Buraydah, Saudi Arabia.
Maha A AlwailiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. BOX 84428, 11671, Riyadh, Saudi Arabia.
Faris F Aba AlkhaylDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 51452, Buraydah, Saudi Arabia.
Al Mokhtar LamsabhiDepartamento de Química and Institute for Advanced Research in Chemical Science (IAdChem), Facultad de Ciencias, Universidad Autónoma de Madrid, Módulo 13, 28049, Madrid, Spain.

Funding

Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University PNURSP2025R227Ministerio de Ciencia, Innovación y Universidades PID2023-150717NB-I00
6 · The paper itself

Abstract

Herein, nine coumarins were isolated and characterized from Ammi visnaga, prompting a comprehensive evaluation of their pharmacological potential. An in silico target selection approach was initially employed to identify plausible protein targets, which, combined with a repurposing rationale, prioritized squalene epoxidase (SQLE) for detailed investigation. The in vitro SQLE inhibition assay demonstrated that khellin, khellol, and visnagin exhibited low-micromolar IC

Indexed as

Enzyme InhibitorsFurocoumarinsLipid MetabolismPhytochemicalsSqualene MonooxygenaseComputer SimulationDrug RepositioningKineticsMolecular Docking SimulationMolecular Dynamics SimulationEnzyme InhibitorsFurocoumarinsPhytochemicalsSqualene MonooxygenaseEnzyme kineticsFuranocoumarinsIn silicoIn vitro studyLipid metabolism disruptionSqualene epoxidase

Identifiers

PMID41369721

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.