Evidence map›Paper›PMID 41369835›Full record

ReviewFolia microbiologica2026

Epstein-Barr virus and human MiRNAs crosstalk: orchestrating latency, lytic cycle, and immune system modulation.

Reda M Mansour, Gharieb S El-Sayyad, Mohamed Hemdan, Nehal I Rizk, Sherif S Abdel Mageed, Osama A Mohammed, Ahmed Mahdy, Khaled Abuelhaded, Shimaa A Farag, Reem K Shahin and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Folia microbiologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. miRNA profiling in pediatric and young adult Burkitt leukemia and lymphoma.Virchows Archiv : an international journal of pathology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Reda M MansourZoology and Entomology Department, Faculty of Science, Helwan University, Helwan, Egypt.
Gharieb S El-SayyadDepartment of Medical Analysis Technology, Faculty of Applied Health Sciences Technology, Badr University in Cairo (BUC), Cairo, Egypt. Gharieb.El-Saied@buc.edu.eg.ORCID http://orcid.org/0000-0001-5410-7936
Mohamed HemdanSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Nehal I RizkDepartment of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, 11786, Egypt.
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.
Ahmed MahdyMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Khaled AbuelhadedSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Shimaa A FaragSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Reem K ShahinDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Yara A NassarDepartment of Botany, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Hamed M El-ShoraDepartment of Botany, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Rokia AminSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt. ahmed_doghish@azhar.edu.eg.ORCID http://orcid.org/0000-0002-0136-7096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that establishes lifelong latency in its host and is associated with a range of malignancies and immune-related disorders. This review examines the complex interactions between EBV and microRNAs (miRNAs), small, non-coding RNAs that regulate gene expression at the post-transcriptional level. It focuses on EBV-encoded miRNAs derived from the BHRF1 and BART clusters, detailing their distinct functions during different latency phases and viral reactivation. These miRNAs facilitate immune evasion, modulate cell cycle progression, apoptosis, and differentiation, and promote cellular environments that favor viral persistence and oncogenesis. EBV also disrupts host miRNA networks, altering gene expression and immune regulation, which contributes to tumor development in diseases such as Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's lymphoma, and post-transplant lymphoproliferative disorders, and has additionally emerged as a leading etiological factor in multiple sclerosis. Furthermore, the review highlights how viral and host miRNAs jointly modulate immune checkpoints, antiviral defense mechanisms, and the tumor microenvironment. It concludes by summarizing recent progress in miRNA-based diagnostics and therapeutics, underscoring their potential for advancing personalized medicine in EBV-associated pathologies.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanMicroRNAsVirus LatencyHost-Pathogen InteractionsHumansVirus ActivationMicroRNAsAdaptive immunityEpstein-Barr virusInnate immunityLatencyLytic reactivationMicroRNAs

Identifiers

PMID41369835

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.