Evidence map›Paper›PMID 41369898›Full record

ArticleAbdominal radiology (New York)2026

Reduced visceral adipose tissue area linked to early recurrence in HCC patients with HBV: a parallel mediation analysis.

Liping Zuo, Yueming An, Xiaoyun Liu, Bowen Wang, Linlin Lang, Zimeng Yang, Zhanyu Zhou, Weijia Zhao, Jinlei Fan, Xin Lin and 3 more

Abstract read
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Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Liping Zuo *Department of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Yueming An *Department of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Xiaoyun LiuDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Bowen WangDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Linlin LangDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Zimeng YangDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Zhanyu ZhouDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Weijia ZhaoDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Jinlei FanDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Xin LinDepartment of Breast Imaging, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jingjing ChenDepartment of Breast Imaging, The Affiliated Hospital of Qingdao University, Qingdao, China.
Na ZhuDepartment of Clinical Laboratory, Qilu Hospital of Shandong University, Qingdao, China. 15665778532@163.com.
Dexin YuDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China. yudexin0330@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to evaluate the relationship between abdominal fat, as quantified by magnetic resonance imaging (MRI), and early postoperative recurrence (≤ 2 years) in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), with an emphasis on identifying potential mediators.

methodWe enrolled HCC patients with HBV infection who underwent preoperative MRI and hepatectomy between January 2015 and October 2021. The visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured at the third lumbar vertebra plane on T1-weighted images and compared between patients with and without early recurrence. Multivariate logistic regression models identified risk factors for early recurrence, which were then visualized in a nomogram. Mediation analysis assessed whether mediators explained the relationship between abdominal fat and early recurrence.

resultThe study included 146 HBV-related HCC patients from institution A (internal cohort) and 76 from institution B (external validation cohort). Results showed that patients with early recurrence had smaller VAT areas (P

conclusionReduced VAT areas influence early recurrence in HBV-related HCC, with MVI and tumor size acting as mediators.

Indexed as

Carcinoma, HepatocellularHepatitis BIntra-Abdominal FatLiver NeoplasmsMagnetic Resonance ImagingNeoplasm Recurrence, LocalAgedFemaleHepatectomyHumansMaleMediation AnalysisMiddle AgedRetrospective StudiesRisk FactorsHepatitis B virusHepatocellular carcinomaMagnetic resonance imagingMediation analysisVisceral adipose tissue

Identifiers

PMID41369898

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.