Evidence map›Paper›PMID 41370341›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Endogenous forms of ATP-ATP

Jin Wang, Li Guan, Ting-Ting Wang, Tang-Xuan Xie, Yi-Yu Lin, Meng-Yang Sun, Dong-Ping Wang, Xue Zhang, Yu-Jing Bian, Chen-Xi Yue and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jin Wang *Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.ORCID 0000-0001-8337-0434
Li Guan *Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Ting-Ting Wang *Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Tang-Xuan Xie *Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.ORCID 0009-0006-0084-4782
Yi-Yu LinDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Meng-Yang SunDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Dong-Ping WangDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Xue ZhangDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yu-Jing BianDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Chen-Xi YueDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Bei-Bei DingDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Xue-Fei MaDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Ye YuDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.ORCID 0000-0002-4054-8543

Funding

High Level Innovation and Entrepreneurial Research Team Program in Jiangsu (Expert Teams of Program of Innovation and Entrepreneurship of Jiangsu Province) JSSCTD202350JST | Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation) BK20202002MOST | National Natural Science Foundation of China (NSFC) 32371289MOST | National Natural Science Foundation of China (NSFC) 32471203
6 · The paper itself

Abstract

P2X receptors, a family of ATP-activated ion channels, encompass subtypes P2X1-7, which are expressed in both homo- and heterotrimeric forms across various tissues. These receptors play crucial roles in pathophysiological processes such as synaptic transmission, nociception, cough, and taste perception. Extracellular ATP exists as both MgATP

Indexed as

Adenosine TriphosphateReceptors, Purinergic P2X3Signal TransductionAnimalsCoughHEK293 CellsHumansMiceMice, TransgenicAdenosine TriphosphateReceptors, Purinergic P2X3allosteric modulationbiased activationcoughion channelP2X receptors

Identifiers

PMID41370341
PMCPMC12718370

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.