Brainstem circuit for sickness-induced sleep.

Dana Darmohray, Jiao Sima, Chien-Hao Chen, Daniel Silverman, Changwan Chen, Ashley Xu, Yuanyuan Yao, Yang Dan

Abstract read

In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Evolution and Reorganization of the Hierarchical Brain-wide Neuronal Network Through Anesthesia.Neuroscience bulletin · 2026
Article
A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026
Article
HSV-1 reactivation as an emergent property of neuronal stress: implications for traumatic brain injury.Journal of neuroinflammation · 2026
Review
Brain Structures, Circuits, and Networks Involved in Immune Regulation, Periodontal Health, and Disease.Life (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dana DarmohrayDepartment of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

Jiao SimaDepartment of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-5545-2587

Chien-Hao ChenDepartment of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0007-7793-9752

Daniel SilvermanDepartment of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3502-3742

Changwan ChenDepartment of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-2520-8516

Ashley XuDepartment of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0001-9149-8371

Yuanyuan YaoInstitute of Neuromodulation and Cognition (INC), Shenzhen Medical Academy of Research and Translation (SMART), Shenzhen 518107, Guangdong, China.

Yang DanDepartment of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3818-877X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased sleep induced by immune activation plays a crucial role in facilitating recovery from illness. However, the neural mechanisms underlying sickness-induced sleep remain poorly understood. Here, we identify a brainstem circuit originating in the nucleus of the solitary tract (NST) that mediates sickness-induced nonrapid eye movement (NREM) sleep. Using activity-dependent genetic labeling, we tagged NST neurons activated by lipopolysaccharide (LPS) injection and showed that their chemogenetic activation strongly promotes NREM sleep. These NST neurons project extensively to the parabrachial nucleus (PB), where LPS-activated neurons also promote NREM sleep. Fiber photometry recording of several wake-promoting neuromodulators using their biosensors showed that evoked norepinephrine release from locus coeruleus neurons is markedly reduced by either LPS injection or direct activation of NST or PB sickness neurons. These results suggest that sickness-induced NREM sleep is mediated in part by a brainstem circuit that regulates neuromodulator signaling.

Indexed as

Brain StemSleepAnimalsLipopolysaccharidesLocus CoeruleusMaleMiceMice, Inbred C57BLNeuronsNorepinephrineParabrachial NucleusLipopolysaccharidesNorepinephrine

Identifiers

PMID41370374

DOI10.1126/sciadv.ady0245

PMCPMC12693964

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Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.