Evidence map›Paper›PMID 41370396›Full record

ArticleScience advances2025

Repair of female reproductive function by GDF-9-overexpressing extracellular vesicles via ACVR1B/SMAD2 regulation in ovarian granulosa.

Sichen Zhang, Huidong Liu, Tianyue Zhang, Yansong Wang, Mengtong Zhang, Xiao Zhang, Hansong Li, Shuai Huang, Lin Liang, Ke Cheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sichen ZhangDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0000-0002-8809-2063
Huidong LiuDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0000-0001-9984-0779
Tianyue ZhangDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0009-0005-4670-3603
Yansong WangDepartment of Research and Development, China Resources Zizhu Pharmaceutical Co. Ltd., No. 27, Chaoyang North Road, Chaoyang District, Beijing 100024, China.ORCID 0009-0004-0013-0785
Mengtong ZhangDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0009-0006-4970-7359
Xiao ZhangDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0000-0003-1831-1475
Hansong LiDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0000-0002-7434-1022
Shuai HuangDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0000-0002-5398-0984
Lin LiangDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0009-0005-6471-4373
Ke ChengDepartment of Biomedical Engineering, Columbia University, NY, New York 10032, USA.ORCID 0000-0001-8053-7059
Shaowei WangDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, PR, China.ORCID 0000-0001-9423-3785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging in females is characterized by dysfunctional ovaries (DOs). While human umbilical cord mesenchymal stem cell (HucMSC)-derived extracellular vesicles (EVs) have shown promise in ameliorating DO, the mechanisms underlying their effects remain poorly understood. In this study, we investigated the therapeutic potential of growth differentiation factor 9 (GDF-9)-overexpressing EVs (GOEs) on granulosa cells. We identified the activin A receptor type 1B (ACVR1B) as a critical target for the restoration of ovarian function. Genetic modification of HucMSCs to overexpress GDF-9 resulted in the production of GOEs, which, through ACVR1B activation, induced SMAD2 phosphorylation in the nucleus, thereby rescuing ovarian function. These findings provide previously unknown insights into the mechanisms by which EVs mediate ovarian recovery and propose GOEs as a potential therapeutic strategy for the treatment of DO.

Indexed as

Activin Receptors, Type IExtracellular VesiclesGranulosa CellsGrowth Differentiation Factor 9Smad2 ProteinAnimalsFemaleHumansMesenchymal Stem CellsOvaryPhosphorylationSignal TransductionActivin Receptors, Type IACVR1B protein, humanGDF9 protein, humanGrowth Differentiation Factor 9Smad2 ProteinSMAD2 protein, human

Identifiers

PMID41370396
PMCPMC12693986

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.