Evidence map›Paper›PMID 41371627›Full record

ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2026

Analytical Assessment of Hyaluronan and Its Heavy Chain Modification with Solid-State Nanopore Sensors.

Dorothea A Erxleben, Suruchi Poddar, Mohamed Amin Elaguech, Adam R Hall

Abstract readReview
In one paragraph

Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dorothea A ErxlebenVirginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA; email: adam.hall@wfusm.edu.
Suruchi PoddarVirginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA; email: adam.hall@wfusm.edu.
Mohamed Amin ElaguechVirginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA; email: adam.hall@wfusm.edu.
Adam R HallVirginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA; email: adam.hall@wfusm.edu.

Funding

Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale ElectrophoresisP41EB020594 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Steven Allan Soper · 2015 to 2026
$15.2M
Solid-state nanopores for translational analysis of hyaluronan abundance and size distributionR01GM134226 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Adam Roger Hall · 2020 to 2026
$2.3M
NIBIB NIH HHS P41 EB020594NIGMS NIH HHS R01 GM134226
6 · The paper itself

Abstract

Hyaluronan (HA) is an essential polysaccharide found throughout nature where it serves diverse biological roles in a broad range of fundamental biological processes and diseases. A critical aspect of HA is its molecular weight (MW), which varies from a few disaccharides to polymers tens of megadaltons in length. Because the behavior of HA depends distinctly on size, there is great interest in the accurate determination of its MW distribution in different conditions. A solution is presented by the solid-state nanopore platform in which HA molecules are probed individually as they pass electrically through a fabricated pore. The approach has been built into a sensitive and quantitative tool for HA MW assessment through process optimization and coupling with specific HA extraction protocols. These developments have enabled it to be applied to several outstanding biological questions, including the emergent role of heavy chain-modified HA.

Indexed as

Hyaluronic AcidNanoporesHumansMolecular WeightHyaluronic Acidglycosaminoglycansheavy-chain hyaluronanhyaluronanmolecular weight distributionsingle-molecule detectionsolid-state nanopores

Identifiers

PMID41371627
PMCPMC13282824

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.