Evidence map›Paper›PMID 41371719›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2025

Systematic review of changes in extracellular vesicles associated with obstructive sleep apnoea: implications for diagnosis and treatment.

Bárbara Santos, Bárbara Ramalho, Angela Relógio, Cláudia Cavadas, Laetitia S Gaspar, Ana Rita Álvaro

Abstract readSystematic Review
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bárbara SantosCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0002-2681-5967
Bárbara RamalhoCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Angela RelógioInstitute for Systems Medicine and Faculty of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany.
Cláudia CavadasCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Laetitia S GasparCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Ana Rita ÁlvaroCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal ritaa80@cnc.uc.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnoea (OSA) is a major public health concern, strongly linked to cardiovascular disease and cancer. Extracellular vesicles (EVs) have emerged as key mediators in intercellular communication, oxidative stress and inflammation, carrying molecules that can influence OSA pathophysiology. However, their role in OSA pathophysiology remains underexplored. This systematic review consolidates current research on EVs in OSA, focusing on their cargo, surface proteins and impact on oxidative stress, inflammation, cancer progression and cardiovascular dysfunction. Registered in the International Prospective Register of Systematic Reviews (ID CRD 42024537136), it explores the intricate links between OSA and EVs to uncover disease mechanisms and identify potential biomarkers. The search was conducted in PubMed/Medline and Web of Science databases to identify studies exploring OSA and EVs in clinical studies, animal studies and

Indexed as

Extracellular VesiclesSleep Apnea, ObstructiveAnimalsBiomarkersHumansInflammation MediatorsNeoplasmsOxidative StressPredictive Value of TestsPrognosisProteomicsRisk FactorsBiomarkersInflammation Mediators

Identifiers

PMID41371719
PMCPMC12690371

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.