Evidence map›Paper›PMID 41371958›Full record

ArticleLife science alliance2026

Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.

Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Monika Horbacz, Bożena Bruhn-Olszewska, Kinga Drężek-Chyła, Mikołaj Koszyński, Hanna Davies, Ulana Juhas, Magdalena Wójcik-Zalewska, Alicja Klich-Rączka and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Edyta Rychlicka-Buniowska3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland edyta.rychlicka-buniowska@gumed.edu.pl.ORCID 0000-0001-8050-2489
Daniil SarkisyanDepartment of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Monika Horbacz3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland.
Bożena Bruhn-OlszewskaDepartment of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2141-0247
Kinga Drężek-Chyła3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland.
Mikołaj Koszyński3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland.
Hanna DaviesDepartment of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Ulana Juhas3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland.ORCID 0000-0001-8393-5845
Magdalena Wójcik-Zalewska3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland.
Alicja Klich-RączkaDepartment of Internal Medicine and Gerontology, Jagiellonian University Medical College, Kraków, Poland.ORCID 0000-0002-9311-0078
Lena KilanderDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Martin IngelssonDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Karolina Bukowska-StrakovaDepartment of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.ORCID 0000-0001-9181-439X
Kazimierz WęglarczykDepartment of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.
Maciej SiedlarDepartment of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.ORCID 0000-0002-3904-5412
Jarosław BaranDepartment of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.
Janusz RyśDepartment of Tumor Pathology, Maria Skłodowska-Curie National Research Institute of Oncology, Kraków, Poland.
Arkadiusz Piotrowski3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland.
Natalia Filipowicz3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland.ORCID 0000-0002-9673-2649
Jan P Dumanski3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland jan.dumanski@igp.uu.se.ORCID 0000-0002-1489-1452

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events with implications for aging and Alzheimer disease (AD). LOY is linked to increased AD risk, whereas CHIP may be protective, and their co-occurrence remains unclear. We conducted whole-exome sequencing of CD4

Indexed as

Alzheimer DiseaseChromosomes, Human, YClonal HematopoiesisMutationAgedAged, 80 and overCD4-Positive T-LymphocytesExome SequencingFemaleHumansKiller Cells, NaturalMaleMiddle AgedMyeloid Cells

Identifiers

PMID41371958
PMCPMC12696397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.