Evidence mapPaperPMID 41372103Full record

SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2026

Impacts of Lifestyle and Microbiota-Targeted Interventions for Overweight and Obesity on the Human Gut Microbiome: A Systematic Review.

Yee Teng Lee, Ayça Akan, Dilara Beyza Önel, Evelyn Medawar, Daria E A Jensen, Arno Villringer, A Veronica Witte

Abstract readSystematic Review
In one paragraph

Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yee Teng LeeClinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.ORCID 0000-0002-8255-6234
Ayça AkanDepartment of Neurology, Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig, Germany.
Dilara Beyza ÖnelDepartment of Neurology, Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig, Germany.
Evelyn MedawarDepartment of Neurology, Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig, Germany.
Daria E A JensenClinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.
Arno VillringerClinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.ORCID 0000-0003-2604-2404
A Veronica WitteClinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.

Funding

German Research Foundation (DFG) 209933838German Research Foundation (DFG) WI 3342/3-1Max Planck Society
6 · The paper itself

Abstract

Obesity is intricately associated with the gut microbiome, and emerging research suggests that lifestyle interventions, such as dietary changes and active lifestyle, can significantly affect the composition and function of the gut microbiome. However, evidence demonstrating a causal link between these changes and long-term weight loss or metabolic improvements remains limited. This systematic review investigates how overweight- and obesity-targeted interventions, such as dietary modifications, physical activity, supplementation with prebiotics and probiotics, and fecal microbiota transplantation (FMT), manipulate gut microbiome diversity and composition, major metabolites, and weight status. We conducted a systematic literature search and included 87 out of 255 randomized clinical trials with 6086 adults aged 18-84 with a BMI ≥ 25 kg/m

Indexed as

Gastrointestinal MicrobiomeLife StyleObesityOverweightAdultAgedExerciseFecal Microbiota TransplantationHumansMiddle AgedPrebioticsProbioticsRandomized Controlled Trials as TopicPrebioticsgut microbiomelifestyle interventionsobesityrandomized controlled trials

Identifiers

PMID41372103
PMCPMC12926627

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.