Evidence map›Paper›PMID 41372118›Full record

ReviewNature communications2025

The promise of organ rejuvenation to overcome the shortage in organ transplantation.

Mukhammad Kayumov, Zhuolun Song, Friederike Martin, Sarah Tsou, Yao Xiao, Hao Zhou, Stefan G Tullius

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mukhammad KayumovDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5533-3270
Zhuolun SongDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5101-3950
Friederike MartinDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sarah TsouDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yao XiaoDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0062-9813
Hao ZhouDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9109-2489
Stefan G TulliusDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. stullius@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-3058-3166

Funding

The KAPP-Sen Tissue Mapping Center CollaborativeU54AG075941 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GAROVIC, VESNA D, KUCHEL, GEORGE A · 2021 to 2025
$13.8M
Nano Immune-Imaging CoreP01AI175397 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Reza Abdi · 2024 to 2026
$9.5M
Senescent cells drive mt-DNA accumulation and inflamm-agingR01AG064165 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2020 to 2024
$2.6M
Understanding Interorgan Communication Through Heterochronic Organ TransplantationU01AG086168 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Vadim N. Gladyshev, Stefan Gunther Tullius · 2024 to 2026
$2.0M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) 5P01AI175397-02NIAID NIH HHS P01 AI175397NIA NIH HHS R01 AG064165NIA NIH HHS U01 AG086168NIA NIH HHS U54 AG075941
6 · The paper itself

Abstract

Organ shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered. A substantial number of organs, particularly from older donors, remain unused due to concerns over age-related decline in quality. This review highlights emerging strategies to rejuvenate and optimize such organs by mitigating ischemia-reperfusion injury and reducing age-related immunogenicity. Advances in organ preservation, perfusion technologies, and novel therapies - including senotherapeutics, anti-inflammatory agents, and stem cell treatments - show promise in improving graft viability and bridging the gap between organ supply and demand.

Indexed as

Organ PreservationOrgan TransplantationRejuvenationTissue and Organ ProcurementAnimalsHumansReperfusion InjuryTissue Donors

Identifiers

PMID41372118
PMCPMC12717245

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.