Evidence map›Paper›PMID 41372176›Full record

ArticleNature communications2025

The balance between stability and plasticity of the visual word form area in dyslexia.

Jamie L Mitchell, Maya Yablonski, Hannah L Stone, Mia Jimenez, Megumi E Takada, Kenny A Tang, Jasmine E Tran, Clementine Chou, Jason D Yeatman

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Anatomy of the Visual Word Form Area in Dyslexia.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Sulcal anatomy of ventral temporal cortex and reading development.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jamie L MitchellGraduate School of Education, Stanford University, Stanford, CA, USA. jamiel12@stanford.edu.ORCID http://orcid.org/0009-0002-0854-1875
Maya YablonskiGraduate School of Education, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4432-5275
Hannah L StoneDepartment of Psychological & Brain Sciences, University of California, Santa Baraba, CA, USA.ORCID http://orcid.org/0009-0003-3002-6199
Mia JimenezGraduate School of Education, Stanford University, Stanford, CA, USA.
Megumi E TakadaGraduate School of Education, Stanford University, Stanford, CA, USA.
Kenny A TangDepartment of Special Education, Peabody College of Education and Human Development, Vanderbilt University, Nashville, TN, USA.
Jasmine E TranSchool of Education, University of California, Irvine, CA, USA.
Clementine ChouGraduate School of Education, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6396-7919
Jason D YeatmanGraduate School of Education, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2686-1293

Funding

Neural mechanisms of successful intervention in children with dyslexiaR01HD095861 · NICHD · STANFORD UNIVERSITY · PI YEATMAN, JASON D · 2019 to 2024
$3.1M
NICHD NIH HHS R01 HD095861
6 · The paper itself

Abstract

Understanding the balance between plastic and persistent traits in the dyslexic brain is critical for developing effective interventions. This longitudinal intervention study examines the Visual Word Form Area in dyslexic and typical readers, exploring how this key component of the brain's reading circuitry changes with learning. We find that children with dyslexia show significant differences in Visual Word Form Area presence, size, and tuning properties compared to typical readers. While reading intervention improves reading skills and increases Visual Word Form Area size, disparities persist a year later, suggesting that Visual Word Form Area abnormalities are enduring traits of dyslexia. Our results reveal long-term neural and behavioral changes, while also elucidating stable differences in the functional architecture of the dyslexic brain. This work provides comprehensive insights into the potential and limitations of short-term learning-induced plasticity in human visual cortex.

Indexed as

DyslexiaNeuronal PlasticityVisual CortexAdolescentChildFemaleHumansLearningLongitudinal StudiesMagnetic Resonance ImagingMaleReading

Identifiers

PMID41372176
PMCPMC12796487

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.