Evidence map›Paper›PMID 41372246›Full record

ArticleNature communications2025

Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo.

Inka Rapöhn, Helen Broghammer, Anne Hoffmann, Kevin Möhlis, Anna Moormann, Isabell Kaczmarek, Doreen Thor, Henning Großkopf, Laura Krieg, Isabel Karkossa and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Inka Rapöhn *Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-7997-5334
Helen BroghammerHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Anne HoffmannHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-3258-3397
Kevin MöhlisHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Anna MoormannHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Isabell KaczmarekRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-9774-3959
Doreen ThorRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-9522-5098
Henning GroßkopfDepartment Molecular Toxicology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.ORCID http://orcid.org/0000-0002-5122-2477
Laura KriegDepartment Molecular Toxicology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.
Isabel KarkossaDepartment Molecular Toxicology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.ORCID http://orcid.org/0000-0003-2781-1877
Kristin SchubertDepartment Molecular Toxicology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.ORCID http://orcid.org/0000-0003-4365-084X
Martin von BergenDepartment Molecular Toxicology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.ORCID http://orcid.org/0000-0003-2732-2977
Kerstin KrauseLeipzig University Medical Center, Divisions of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-1766-3698
Jana BreitfeldLeipzig University Medical Center, Divisions of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-8346-8087
Peter KovacsLeipzig University Medical Center, Divisions of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-0290-5423
Nora KlötingHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Rima NuwayhidDepartment of Orthopaedic, Trauma and Plastic Surgery, Division of Plastic, Aesthetic and Special Hand Surgery, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-7587-1968
Stefan LangerDepartment of Orthopaedic, Trauma and Plastic Surgery, Division of Plastic, Aesthetic and Special Hand Surgery, University Hospital Leipzig, Leipzig, Germany.
Adhideb GhoshLaboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland.
Christian WolfrumLaboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland.ORCID http://orcid.org/0000-0002-3862-6805
Michael StumvollHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-6225-8240
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-0208-2065
John T HeikerHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany. john.heiker@helmholtz-munich.de.ORCID http://orcid.org/0000-0003-2822-3006
Juliane Weiner *Leipzig University Medical Center, Divisions of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 209933838
6 · The paper itself

Abstract

Altered activity of brown adipose tissue (BAT) contributes to obesity, insulin resistance, and cardiovascular disease. BAT secretes endocrine factors ("batokines") that regulate thermogenesis. We identify the serpin vaspin as a batokine that modulates adrenergic control of lipolysis and thermogenesis. Adipocyte-specific vaspin overexpression in mice reduces BAT activation and impairs thermoregulation during cold exposure or fasting. Mechanistically, vaspin binds low-density lipoprotein receptors (LRP1, LDLR, vLDLR), inhibiting adrenergic signaling and lipolysis in brown and white adipocytes by modulating phosphodiesterase activity and endocytic lipid uptake. Gene set enrichment analyses in human subcutaneous adipose tissue and in vitro studies confirm vaspin's anti-lipolytic effects in humans. Overall, vaspin emerges as a regulatory BATokine that fine-tunes BAT thermogenic activity to limit excessive energy expenditure and preserve metabolic balance.

Indexed as

AdipocytesBody Temperature RegulationLipolysisSerpinsAdipokinesAdipose Tissue, BrownAnimalsEnergy MetabolismFemaleHumansMaleMiceMice, Inbred C57BLReceptors, LDLSignal TransductionThermogenesisAdipokinesReceptors, LDLSERPINA12 protein, humanSerpinsvaspin protein, mouse

Identifiers

PMID41372246
PMCPMC12698850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.