Evidence map›Paper›PMID 41372348›Full record

ArticleScientific reports2025

Dynamic and functional changes in vascular endothelial cell monolayers under combined hypoxic and inflammatory stimuli.

Kazuki Sone, Ai Funatsu, So Sampei, Kenichi Funamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kazuki SoneGraduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aramaki-aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8579, Japan.
Ai FunatsuInstitute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi, 980-8577, Japan.
So SampeiDepartment of Emergency and Critical Care Medicine, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Kenichi FunamotoGraduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aramaki-aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8579, Japan. funamoto@tohoku.ac.jp.

Funding

Japan Science and Technology Agency JPMJPR22O8Japan Science and Technology Agency JPMJSP2114Japan Society for the Promotion of Science 23K15623
6 · The paper itself

Abstract

In sepsis, dysregulated inflammatory responses cause microthrombi formation, leading to organ hypoxia. While endothelial cell (EC) responses to inflammation are well-studied, the combined effects of hypoxia and inflammation remain unclear. We investigated EC dynamics and function under simultaneous hypoxia and lipopolysaccharide (LPS) exposure using microfluidic devices with controllability of oxygen concentration. Collective cell migration was measured by particle image velocimetry, while monolayer permeability was assessed by diffusion of fluorescently labeled dextran. Additionally, we examined adhesion and signaling protein expression. Migration speed decreased under approximately 1% O

Indexed as

Endothelial CellsInflammationCell AdhesionCell HypoxiaCell MovementHumansHuman Umbilical Vein Endothelial CellsHypoxia-Inducible Factor 1, alpha SubunitIntercellular Adhesion Molecule-1LipopolysaccharidesNF-kappa BSignal TransductionVascular Cell Adhesion Molecule-1Hypoxia-Inducible Factor 1, alpha SubunitIntercellular Adhesion Molecule-1LipopolysaccharidesNF-kappa BVascular Cell Adhesion Molecule-1Collective cell migrationHypoxiaInflammatory responseLipopolysaccharideMicrofluidic deviceSepsisVascular endothelial cellsVascular permeability

Identifiers

PMID41372348
PMCPMC12800060

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.