Evidence map›Paper›PMID 41372470›Full record

ArticleCellular and molecular life sciences : CMLS2025

TCF7L2 is essential for the differentiation and invasive function of human extravillous trophoblast.

Enoch Appiah Adu-Gyamfi, Joudi Salamah, Elisha Cheeran, Brandt Beck, Zaineb Ahmad, Bum-Kyu Lee

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Enoch Appiah Adu-GyamfiDepartment of Biomedical Sciences, Cancer Research Center, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, 12222, USA.
Joudi SalamahDepartment of Biomedical Sciences, Cancer Research Center, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, 12222, USA.
Elisha CheeranDepartment of Biomedical Sciences, Cancer Research Center, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, 12222, USA.
Brandt BeckDepartment of Biomedical Sciences, Cancer Research Center, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, 12222, USA.
Zaineb AhmadDepartment of Biomedical Sciences, Cancer Research Center, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, 12222, USA.
Bum-Kyu LeeDepartment of Biomedical Sciences, Cancer Research Center, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, 12222, USA. blee6@albany.edu.ORCID http://orcid.org/0000-0001-7835-419X

Funding

University at Albany Start-up fund
6 · The paper itself

Abstract

Extravillous trophoblasts (EVTs) play essential roles in placental development by anchoring the placenta, invading the maternal decidua, and remodeling spiral arteries. TCF7L2 is known to be expressed in human placental tissues and EVTs, and it controls EVT motility. However, the targets of TCF7L2 in trophoblasts and the mechanism by which it contributes to early trophoblast differentiation are largely unknown. Here, using trophoblast stem cells (TSCs), we investigate the expression patterns of TCF7L2 during trophoblast lineage differentiation, revealing that its expression gradually elevates throughout EVT formation. Loss-of-function studies uncover that TCF7L2 is implicated in the proliferation of TSCs and is essential for EVT formation. Conversely, overexpression of TCF7L2 hinders TSC differentiation into STs. We identify TCF7L2 binding sites across the genome in TSCs and EVTs. Integrative analyses of TCF7L2 targets with global gene expression profiles unveil that TCF7L2 facilitates EVT formation by directly activating extracellular matrix organization while suppressing genes linked to the cell cycle. Moreover, overlap analyses of TCF7L2 targets with those of other EVT factors reveal that TCF7L2 collaborates with other EVT factors to promote EVT formation. In summary, our findings highlight context-specific functions of TCF7L2 in the trophoblast lineage.

Indexed as

Cell DifferentiationTranscription Factor 7-Like 2 ProteinTrophoblastsCell MovementCell ProliferationExtracellular MatrixExtravillous TrophoblastsFemaleHumansPlacentaPregnancyStem CellsTCF7L2 protein, humanTranscription Factor 7-Like 2 ProteinExtravillous trophoblastPlacental developmentTCF7L2 transcription factorTrophoblast lineage differentiationTrophoblast stem cells

Identifiers

PMID41372470
PMCPMC12775252

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.