ArticleArchives of virology2025
Equid alphaherpesvirus 1 (EHV-1) infection of primary murine astrocytes: role of the cytoskeleton.
Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nucleic acid detection and molecular traceability of equine herpesvirus 1 in imported horses.Frontiers in microbiology · 2026Article
- Genome-wide CRISPR/Cas9 screening identifies host factors critical for antiviral defense against equine herpesvirus type 1.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Equid alphaherpesvirus type 1 (EHV-1) is a neurotropic virus known to manipulate host cytoskeletal structures to facilitate infection and spread. In this study, we examined the susceptibility of primary murine astrocytes to neuropathogenic and non-neuropathogenic EHV-1 strains, focusing on the role of the actin and microtubule cytoskeleton. Infection induces morphological changes and remodeling of actin and microtubule networks. Viral antigen was localized along actin filaments and microtubules, indicating their likely role in intracellular viral trafficking. Cytoskeletal inhibitors significantly reduced viral DNA levels. Both EHV-1 strains exhibited limited replication, suggesting that EHV-1 may establish abortive infection in murine astrocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.