Evidence map›Paper›PMID 41372706›Full record

ArticleMolecular systems biology2026

Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys.

Salma I Abou Elhassan, Josef P Clark, Di Kuang, Timothy W Rhoads, Ricki J Colman, Joshua J Coon, Rozalyn M Anderson, Katherine A Overmyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular systems biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salma I Abou ElhassanDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID http://orcid.org/0000-0002-3452-7949
Josef P ClarkDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Di KuangDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.ORCID http://orcid.org/0009-0001-1586-3621
Timothy W RhoadsDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID http://orcid.org/0000-0001-7364-1122
Ricki J ColmanWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.ORCID http://orcid.org/0000-0001-9706-0525
Joshua J CoonDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Rozalyn M AndersonDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA. rozalyn.anderson@wisc.edu.ORCID http://orcid.org/0000-0002-0864-7998
Katherine A OvermyerDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA. kovermyer@wisc.edu.ORCID http://orcid.org/0000-0002-1929-1229

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI ABBOTT, DAVID H · 1985 to 2011
$106.7M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Dietary Restriction and Aging in Rhesus MonkeysR01AG040178 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ANDERSON, ROZALYN M., COLMAN, RICKI J · 2011 to 2020
$5.8M
Wisconsin Nathan Shock CenterP30AG092586 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, JOHN M DENU · 2025 to 2026
$3.8M
Molecular Networks in Aging and Caloric Restriction in Rhesus MonkeysR01AG074503 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson · 2022 to 2026
$3.1M
HHS | NIH | National Center for Research Resources (NCRR) P51RR000167HHS | NIH | National Institute on Aging (NIA) R01AG040178HHS | NIH | National Institute on Aging (NIA) R01AG074503NCRR NIH HHS P51 RR000167NIA NIH HHS P30 AG092586NIA NIH HHS R01 AG040178NIA NIH HHS R01 AG074503NIGMS NIH HHS P41 GM108538NIH HHS P51 OD011106Office of Research Infrastructure Programs (ORIP) P51OD011106
6 · The paper itself

Abstract

Caloric restriction (CR) without malnutrition delays aging in diverse species, including primates, with metabolic changes implicated in this process. To facilitate exploration of CR metabolism with aging, we developed a 15-minute LC-MS/MS metabolomics and lipidomics method, leveraging monophasic extractions and wide elution-strength solvents. We analyzed 494 plasma samples collected over 25 years from male and female rhesus monkeys (Macaca mulatta) on a Control or CR (30% restricted) diet. Quantitation of 359 biomolecules revealed that aging, followed by sex and diet, had the largest impact on metabolite abundances. In both sexes, aging was associated with significantly lower plasma levels of sphingomyelins (SMs) and higher levels of diglycerides (DGs) and triglycerides (TGs), each of which was opposed by CR. Sex dimorphism was evident by the increased abundance of phosphocholine (PC)-containing lipids in females. These results highlight the utility of a rapid metabolomics and lipidomics approach to elucidate complex biology in large-scale studies.

Indexed as

AgingCaloric RestrictionLipid MetabolismLipidsAnimalsChromatography, LiquidDiglyceridesFemaleLipidomicsMacaca mulattaMaleMetabolomicsSphingomyelinsTandem Mass SpectrometryTriglyceridesDiglyceridesLipidsSphingomyelinsTriglyceridesAgingCaloric RestrictionLipid MetabolismMetabolomicsRhesus Macaque

Identifiers

PMID41372706
PMCPMC12864875

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.