Evidence map›Paper›PMID 41372915›Full record

ReviewGenome biology2025

Ancient genomes give insight into 160,000 years of East Asian population dynamics and biological adaptation.

Guanglin He, Yuntao Sun, Shuhan Duan, Lintao Luo, Qiuxia Sun, Bowen Li, Libing Yun, Chao Liu, Mengge Wang

Abstract readReview
In one paragraph

Review in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guanglin HeDepartment of Laboratory Medicine & Department of Oto-Rhino-Laryngology & Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, 610000, China. guanglinhescu@163.com.ORCID http://orcid.org/0000-0002-6614-5267
Yuntao SunDepartment of Laboratory Medicine & Department of Oto-Rhino-Laryngology & Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, 610000, China. sytao7@163.com.
Shuhan DuanDepartment of Laboratory Medicine & Department of Oto-Rhino-Laryngology & Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, 610000, China. dsh20000422@163.com.
Lintao LuoDepartment of Laboratory Medicine & Department of Oto-Rhino-Laryngology & Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, 610000, China.
Qiuxia SunDepartment of Laboratory Medicine & Department of Oto-Rhino-Laryngology & Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, 610000, China.
Bowen LiDepartment of Laboratory Medicine & Department of Oto-Rhino-Laryngology & Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, 610000, China.
Libing YunCenter for Archaeological Science, Sichuan University, Chengdu, 610000, China. yunlibing@scu.edu.cn.
Chao LiuAnti-Drug Technology Center of Guangdong Province, Guangzhou, 510230, China. liuchaogzf@163.com.
Mengge WangDepartment of Laboratory Medicine & Department of Oto-Rhino-Laryngology & Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, 610000, China. Menggewang2021@163.com.

Funding

National Natural Science Foundation of China 82202078
6 · The paper itself

Abstract

Advances in ancient DNA research have transformed our understanding of human evolution, admixture-driven adaptation, and genetic underpinnings of traits. However, the evolutionary dynamics of Paleolithic and Neolithic East Asian remain fragmented. This review synthesizes 160,000 years of population interactions, highlighting three waves of archaic introgression and extensive population admixtures. We examine how ancestral lineages and agricultural innovations shaped East Asian populations, while migrations and admixture events linked to shifting subsistence strategies contributed to genomic and phenotypic diversity. Adaptive signatures from ancient genomes further elucidate the underpinnings of high-altitude adaptation, pigmentation, and morphological traits, offering new insights into human evolutionary biology.

Indexed as

Adaptation, BiologicalAdaptation, PhysiologicalDNA, AncientEast Asian PeopleGenome, HumanPopulation DynamicsAsia, EasternEvolution, MolecularGenetics, PopulationHumansDNA, AncientAdaptive signaturesAncient DNAArchaic introgressionEvolutionary trajectory

Identifiers

PMID41372915
PMCPMC12690904

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.