Evidence map›Paper›PMID 41373418›Full record

ArticleInternational journal of molecular sciences2025

Isolation of Red Beet Plant-Derived Nanovesicles, and Characterization of Their Molecular Content and Biological Activities in Human Cells.

Clarissa Zanotti, Antonio Dario Troise, Simona Arena, Giovanni Renzone, Sabrina De Pascale, Rosalia Ferracane, Chiara Pontecorvi, Chiara Niespolo, Angelo Gismondi, Andrea Scaloni and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Natural Product-Derived Vesicles in Nanotherapeutics.Journal of extracellular vesicles · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Clarissa ZanottiDepartment of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica 1, 00133 Rome, Italy.
Antonio Dario TroiseProteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, P.le E. Fermi 1, 80055 Portici, Italy.ORCID 0000-0001-7635-5244
Simona ArenaProteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, P.le E. Fermi 1, 80055 Portici, Italy.
Giovanni RenzoneProteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, P.le E. Fermi 1, 80055 Portici, Italy.
Sabrina De PascaleProteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, P.le E. Fermi 1, 80055 Portici, Italy.ORCID 0000-0001-9249-7058
Rosalia FerracaneProteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, P.le E. Fermi 1, 80055 Portici, Italy.
Chiara PontecorviDepartment of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica 1, 00133 Rome, Italy.ORCID 0009-0002-2937-2847
Chiara NiespoloArterra Bioscience SpA, Via Benedetto Brin 69, 80142 Naples, Italy.
Angelo GismondiDepartment of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica 1, 00133 Rome, Italy.ORCID 0000-0002-9257-9667
Andrea ScaloniProteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, P.le E. Fermi 1, 80055 Portici, Italy.ORCID 0000-0001-9362-8515
Mauro MarraDepartment of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica 1, 00133 Rome, Italy.

Funding

National Recovery and Resilience Plan, European Union NextGenerationEU program, mission 4, component 2: investment 1.3, and investment 1,4. MUR DC 1550/2022, PE00000003 ; MUR DD 1032/2022, CN00000022National Recovery and Resilience Plan, European Union NextGenerationEU program, mission 4, component 2, investment 1.4, spoke 2, line 2. CUP E63C22000920005,National Recovery and Resilience Plan, European Union NextGenerationEU program, mission 4, component 2, investment 1.5, spoke 2. CUP E69J24001750003
6 · The paper itself

Abstract

Nowadays, growing evidence indicates that plant-derived nanovesicles cross biological barriers between species, including humans, and deliver therapeutic molecules that influence gene expression, affecting various processes such as inflammation, oxidative stress, and cancer. For these reasons, plant-derived nanovesicles are gaining attention as a valuable substitute for mammalian exosomes as they offer benefits such as reduced immunogenicity, enhanced bioavailability, and the inclusion of beneficial plant metabolites. However, the development of affordable plant-derived nanovesicle-based therapies requires a robust characterization of their molecular structure and cargo, which in turn depends on obtaining sufficient quantities of homogeneous nanovesicle populations. In this study, we used an advanced purification platform combining ultrafiltration and anion exchange chromatography to isolate highly pure plant-derived nanovesicles from a new source,

Indexed as

Beta vulgarisNanoparticlesPlant ExtractsExosomesHumansMicroRNAsProteomicsWound HealingMicroRNAsPlant ExtractsBeta vulgaris L.cross-kingdom regulationlipidomicsmiRNomicsplant-derived nanovesiclesproteomicswound healing

Identifiers

PMID41373418
PMCPMC12691939

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.