Evidence map›Paper›PMID 41373628›Full record

ReviewInternational journal of molecular sciences2025

Aging and Thymosin Alpha-1.

Maria A Simonova, Igor Ivanov, Natalia S Shoshina, Alina M Komyakova, Dmitry A Makarov, Denis S Baranovskii, Ilya D Klabukov, Kristina P Telepenina, Dmitrii A Atiakshin, Peter V Shegay and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria A SimonovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences (IBCh RAS), Ul.Miklukho-Maklaya 16/10, 117997 Moscow, Russia.ORCID 0000-0002-6920-5384
Igor IvanovLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia.ORCID 0000-0003-0543-2067
Natalia S ShoshinaCenter for Synthetic Biotechnology, Sechenov University, 119991 Moscow, Russia.
Alina M KomyakovaCenter for Synthetic Biotechnology, Sechenov University, 119991 Moscow, Russia.
Dmitry A MakarovCenter for Synthetic Biotechnology, Sechenov University, 119991 Moscow, Russia.
Denis S BaranovskiiDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St., 249036 Obninsk, Russia.ORCID 0000-0002-6154-9959
Ilya D KlabukovDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St., 249036 Obninsk, Russia.ORCID 0000-0002-2888-7999
Kristina P TelepeninaCenter for Synthetic Biotechnology, Sechenov University, 119991 Moscow, Russia.
Dmitrii A AtiakshinScientific and Educational Resource Center for Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0002-8347-4556
Peter V ShegayDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St., 249036 Obninsk, Russia.
Andrey D KaprinDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St., 249036 Obninsk, Russia.
Vasiliy N StepanenkoCenter for Synthetic Biotechnology, Sechenov University, 119991 Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is characterized by immune decline, mainly due to thymic involution-the age-related shrinkage of the thymus gland. This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin alpha-1 (Tα1), a peptide hormone produced by the thymus, exhibits potent immunomodulatory, anti-inflammatory, and antioxidant properties. It helps restore immune function by stimulating T-cell differentiation, enhancing thymic output, and modulating dendritic cell and macrophage activity. Preclinical and clinical studies show that Tα1 can improve vaccine response in the elderly and mitigate immunosenescence. The hybrid drug

Indexed as

AgingThymalfasinThymosinAnimalsHumansImmunosenescenceInflammationThymus GlandTumor Necrosis Factor-alphaThymalfasinThymosinTumor Necrosis Factor-alphaagingimmunosenescenceRefnotrejuvenationsenescencethymosin alpha-1thymusTNF-alpha

Identifiers

PMID41373628
PMCPMC12692621

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.