Evidence map›Paper›PMID 41373631›Full record

ArticleInternational journal of molecular sciences2025

Pan-Cancer Analysis Reveals AEBP1-Collagen Co-Expression and Its Potential Role in CAF-Mediated Tumor Stiffness.

Shohei Sekiguchi, Akira Yorozu, Megumi Watanabe, Fumika Okazaki, Satoshi Ohwada, Eiichiro Yamamoto, Takeshi Niinuma, Hiroshi Kitajima, Kazuya Ishiguro, Mitsunobu Saito and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shohei SekiguchiDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Akira YorozuDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Megumi WatanabeDepartment of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8543, Japan.ORCID 0000-0002-8026-6532
Fumika OkazakiDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Satoshi OhwadaDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Eiichiro YamamotoDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Takeshi NiinumaDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Hiroshi KitajimaDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Kazuya IshiguroDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Mitsunobu SaitoDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Masahiro KaiDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Masashi IdogawaDivision of Medical Genome Sciences, Department of Genomic and Preventive Medicine, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.ORCID 0000-0002-8507-1726
Kenichi TakanoDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Sapporo Medical University, Sapporo 060-8543, Japan.ORCID 0000-0001-8706-6384
Akihiro MiyazakiDepartment of Oral Surgery, School of Medicine, Sapporo Medical University, Sapporo 060-8543, Japan.ORCID 0000-0003-3290-6205
Hiroshi OhguroDepartment of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8543, Japan.
Hiromu SuzukiDivision of Molecular Biology, Department of Biochemistry, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.ORCID 0000-0001-9635-3238

Funding

Japan Society for the Promotion of Science KAKENHI 23K24186Japan Society for the Promotion of Science KAKENHI 24K11157Japan Society for the Promotion of Science KAKENHI 24K12676Japan Society for the Promotion of Science KAKENHI 24K20001Japan Society for the Promotion of Science KAKENHI 25K20381Japan Society for the Promotion of Science KAKENHI 25K22694
6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that promote cancer progression and immune evasion. Adipocyte enhancer-binding protein 1 gene (

Indexed as

Cancer-Associated FibroblastsCarboxypeptidasesCollagenNeoplasmsCell Line, TumorExtracellular MatrixGene Expression ProfilingGene Expression Regulation, NeoplasticHumansRepressor ProteinsTumor MicroenvironmentAEBP1 protein, humanCarboxypeptidasesCollagenRepressor Proteins3D spheroidACLPAEBP1CAFcollagentumor stiffness

Identifiers

PMID41373631
PMCPMC12691837

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.