Evidence map›Paper›PMID 41373721›Full record

ArticleInternational journal of molecular sciences2025

Proteomic Exploration of L1CAM

Mary Xylaki, Avika Chopra, Yevheniia Kyriachenko, Jannik Scherer, Birgit Otte, Mohammed Dakna, Michael Bartl, Sandrina Weber, Sebastian Schade, Christof Lenz and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mary XylakiDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0002-7892-8621
Avika ChopraDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Yevheniia KyriachenkoDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0002-4771-1702
Jannik SchererDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0009-0001-8907-1109
Birgit OtteDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Mohammed DaknaDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0001-8341-0360
Michael BartlDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0002-7752-2443
Sandrina WeberDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Sebastian SchadeParacelsus-Elena Klinik, 34128 Kassel, Germany.ORCID 0000-0002-6316-6804
Christof LenzDepartment of Clinical Chemistry, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0002-0946-8166
Brit MollenhauerDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L1 cell adhesion molecule (L1CAM)-positive extracellular vesicles (EVs) are being explored as a potential source of biomarkers for Parkinson's disease (PD) in peripheral blood. However, their utility remains controversial. In this study, we sought to investigate the proteome composition of L1CAM

Indexed as

Extracellular VesiclesNeural Cell Adhesion Molecule L1Parkinson DiseaseProteomeProteomicsAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedProdromal SymptomsREM Sleep Behavior DisorderBiomarkersL1CAM protein, humanNeural Cell Adhesion Molecule L1Proteomebiomarkerextracellular vesiclesiRBDL1CAMParkinson’s disease

Identifiers

PMID41373721
PMCPMC12692637

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.