ArticleInternational journal of molecular sciences2025
The Tetrapeptide HAEE Promotes Amyloid-Beta Clearance from the Brain.
Kristina A Mukhina, Kseniya B Varshavskaya, Aleksandra D Rybak, Viktor V Grishchenko, Elena V Kuzubova, Mikhail V Korokin, Olga I Kechko, Vladimir A Mitkevich
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Kristina A MukhinaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Kseniya B VarshavskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Aleksandra D RybakEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Viktor V GrishchenkoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Elena V KuzubovaResearch Institute of Pharmacology of Living Systems, Belgorod State National Research University, 85 Pobedy St., 308015 Belgorod, Russia.
Mikhail V KorokinResearch Institute of Pharmacology of Living Systems, Belgorod State National Research University, 85 Pobedy St., 308015 Belgorod, Russia.ORCID 0000-0001-5402-0697 Olga I KechkoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Vladimir A MitkevichEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str., 32, 119991 Moscow, Russia.
Funding
Ministry of Science and Higher Education of the Russian Federation (the Federal Scientific-technical Programme for Genetic Technologies Development for 2019-2030) agreement N◦ 075-15-2025-558
6 · The paper itselfAbstract
Alzheimer's disease is characterized by the accumulation of neurotoxic forms of amyloid-beta (Aβ) in the brain, leading to synaptic dysfunction, neuroinflammation, and neuronal death. The tetrapeptide HAEE crosses the blood-brain barrier (BBB), inhibits the formation of toxic Aβ oligomers, and reduces amyloid burden
Indexed as
Amyloid beta-PeptidesBrainOligopeptidesAlzheimer DiseaseAnimalsBlood-Brain BarrierInterleukin-6Low Density Lipoprotein Receptor-Related Protein-1MaleMiceMice, Inbred C57BLMicrogliaTumor Necrosis Factor-alphaAmyloid beta-PeptidesInterleukin-6Low Density Lipoprotein Receptor-Related Protein-1OligopeptidesTumor Necrosis Factor-alphaAlzheimer’s diseaseamyloid-betaAβ clearanceblood–brain barriermicrogliatetrapeptide HAEE
Identifiers
PMID41373742
PMCPMC12692722
What Socratic holds
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