ArticleInternational journal of molecular sciences2025
Modification of Chitosan with (-)-Gossypol and (-)-Gossypol Acetic Acid Using Free-Radical Grafting Method.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
One of the approaches to increase bioavailability and stability of hydrophobic biologically active compounds is their incorporation into polymer backbone. This work deals with the modification of chitosan (CS) with gossypol (GS), a phenolic compound with confirmed anticancer properties, by the free-radical grafting method. The series of the CS derivatives with increasing content of GS were prepared using pure GS or gossypol acetate (GSA) and compared to the control CS (cCS). The starting CS, cCS, and GS-containing derivatives were characterized using Fourier-transform infrared (FTIR), Raman, and
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