Evidence map›Paper›PMID 41373991›Full record

ReviewNutrients2025

Nutritional Modulation of the Gut Microbiome in Relation to Prenatal Lead-Induced Neurotoxicity: A Review.

Shoshannah Eggers, Kiran P Nagdeo, Kshitij Sachdev, Delaney Robinson, Andrea L Deierlein, Jamil M Lane, Chris Gennings, Ryan W Walker, Linda Snetselaar, Nichole Nidey and 2 more

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shoshannah EggersDepartment of Epidemiology, University of Iowa College of Public Health, 145 N. Riverside Drive, Iowa City, IA 52242, USA.ORCID 0000-0002-4321-9219
Kiran P NagdeoDepartment of Epidemiology, New York University School of Global Public Health, 708 Broadway, New York, NY 10003, USA.ORCID 0009-0007-8633-7307
Kshitij SachdevDepartment of Epidemiology, University of Iowa College of Public Health, 145 N. Riverside Drive, Iowa City, IA 52242, USA.
Delaney RobinsonDepartment of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Andrea L DeierleinDepartment of Epidemiology, New York University School of Global Public Health, 708 Broadway, New York, NY 10003, USA.ORCID 0000-0002-2731-4080
Jamil M LaneDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.ORCID 0000-0002-2494-0318
Chris GenningsDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.ORCID 0000-0002-6058-5907
Ryan W WalkerDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.ORCID 0000-0001-8748-0913
Linda SnetselaarDepartment of Epidemiology, University of Iowa College of Public Health, 145 N. Riverside Drive, Iowa City, IA 52242, USA.
Nichole NideyDepartment of Epidemiology, University of Iowa College of Public Health, 145 N. Riverside Drive, Iowa City, IA 52242, USA.
Elizabeth E O'NealDepartment of Community and Behavioral Health, University of Iowa College of Public Health, 145 N. Riverside Drive, Iowa City, IA 52242, USA.
Vishal MidyaDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
Early life metal exposure, the gut microbiome, and neurodevelopment in childhoodR00ES032884 · NIEHS · UNIVERSITY OF IOWA · PI EGGERS, SHOSHANNAH IYLENE · 2023 to 2025
$727k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R00HD102588NIEHS NIH HHS P30 ES005605NIEHS NIH HHS R00ES032884
6 · The paper itself

Abstract

Prenatal exposure to lead (Pb) is a well-established risk factor for adverse neurodevelopmental outcomes. Despite its recognized risks, prenatal Pb exposure remains largely unregulated and poorly addressed in public health policy. Evidence suggests that the gut microbiome may mediate the neurotoxic effects of metals, offering a potential target for intervention. Here we discuss how nutritional factors, particularly those influencing the gut microbiome, may reduce the neurotoxicity of prenatal Pb exposure.

Indexed as

Gastrointestinal MicrobiomeLeadMaternal Nutritional Physiological PhenomenaNeurotoxicity SyndromesPrenatal Exposure Delayed EffectsFemaleHumansPregnancyLeadDevelopmental Origins of Health and Disease (DOHaD)dietgut-brain axisnarrative review

Identifiers

PMID41373991
PMCPMC12694055

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.