Evidence map›Paper›PMID 41374757›Full record

ArticleSensors (Basel, Switzerland)2025

Intraocular Cytokine Level Prediction from Fundus Images and Optical Coherence Tomography.

Hidenori Takahashi, Taiki Tsuge, Yusuke Kondo, Yasuo Yanagi, Satoru Inoda, Shohei Morikawa, Yuki Senoo, Toshikatsu Kaburaki, Tetsuro Oshika, Toshihiko Yamasaki

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hidenori TakahashiCenter for Cyber Medicine Research, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0001-5331-4730
Taiki TsugeDeepEyeVision Inc., Shimotsuke 329-0498, Japan.
Yusuke KondoDeepEyeVision Inc., Shimotsuke 329-0498, Japan.
Yasuo YanagiDepartment of Visual Reconstructive Surgery, Yokohama City University, Yokohama 232-0024, Japan.
Satoru InodaDepartment of Ophthalmology, Jichi Medical University, Shimotsuke 329-0498, Japan.ORCID 0000-0003-4577-8169
Shohei MorikawaDepartment of Ophthalmology, University of Tsukuba, Tsukuba 305-8575, Japan.
Yuki SenooDepartment of Ophthalmology, Nihon University, Tokyo 173-8610, Japan.ORCID 0000-0001-7289-5016
Toshikatsu KaburakiDepartment of Ophthalmology, Jichi Medical University, Shimotsuke 329-0498, Japan.ORCID 0000-0003-1132-6148
Tetsuro OshikaDepartment of Ophthalmology, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0002-9071-7018
Toshihiko YamasakiDepartment of Technology, the University of Tokyo, Tokyo 113-8656, Japan.

Funding

Japan Society for the Promotion of Science 21K09751
6 · The paper itself

Abstract

The relationship between retinal images and intraocular cytokine profiles remains largely unexplored, and no prior work has systematically compared fundus- and OCT-based deep learning models for cytokine prediction. We aimed to predict intraocular cytokine concentrations using color fundus photographs (CFP) and retinal optical coherence tomography (OCT) with deep learning. Our pipeline consisted of image preprocessing, convolutional neural network-based feature extraction, and regression modeling for each cytokine. Deep learning was implemented using AutoGluon, which automatically explored multiple architectures and converged on ResNet18, reflecting the small dataset size. Four approaches were tested: (1) CFP alone, (2) CFP plus demographic/clinical features, (3) OCT alone, and (4) OCT plus these features. Prediction performance was defined as the mean coefficient of determination (R

Indexed as

CytokinesTomography, Optical CoherenceAgedAged, 80 and overAqueous HumorDeep LearningFemaleFundus OculiHumansImage Processing, Computer-AssistedMacular DegenerationMaleMiddle AgedNeural Networks, ComputerRetinaCytokinescytokinedeep-learningoptical coherence tomography

Identifiers

PMID41374757
PMCPMC12694473

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.