Evidence mapPaperPMID 41374792Full record

ReviewPolymers2025

Strategies for Incorporating Natural Therapeutic Agents into Hydrogel Dressings: Innovations in Wound Healing.

Ion Cosmin Călina, Anca Scărișoreanu, Maria Demeter, Elena Mănăilă, Gabriela Crăciun

Abstract readReview
In one paragraph

Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ion Cosmin CălinaNational Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor St., 077125 Măgurele, Romania.ORCID 0000-0003-2828-3471
Anca ScărișoreanuNational Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor St., 077125 Măgurele, Romania.
Maria DemeterNational Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor St., 077125 Măgurele, Romania.ORCID 0000-0003-0758-1445
Elena MănăilăNational Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor St., 077125 Măgurele, Romania.
Gabriela CrăciunNational Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor St., 077125 Măgurele, Romania.

Funding

Ministry of Research, Innovation and Digitization, CNCS - UEFISCDI PN-IV-P2-2.1-TE-2023-0453Romanian Ministry of Education and Research under the Romanian National Core Program LAPLAS VII - Contract no. 30N/2023
6 · The paper itself

Abstract

Effective wound management demands novel therapeutic strategies that overcome the limitations of medication by reducing inflammation, preventing infection, and accelerating tissue regeneration. The present review provides an extensive examination of natural therapeutic agents incorporated into polymeric hydrogels for wound healing purposes. Significant focus has been paid towards extraction techniques that validate the standardization, purity, and biological efficacy of natural compounds, alongside several principal incorporation strategies: direct mixing, in situ incorporation, post-loading, and nano/microencapsulation, aimed at optimizing the stability of bioactive molecules within hydrogel matrices. Representative in vitro and in vivo studies are summarized to highlight the bioactive and therapeutic effects of hybrid systems based on polymeric hydrogels. Collectively, reported evidence indicates that natural-extract-loaded hydrogels accelerate wound healing through multiple complementary mechanisms, including inflammation modulation, antimicrobial protection, moisture balance, and enhanced tissue regeneration. Furthermore, synergistic mixtures of bioactive compounds have demonstrated enhanced antimicrobial and regenerative efficacy compared to single-component formulations. Overall, bioactive hydrogels incorporating standardized or nano-encapsulated natural extracts represent a new generation of multifunctional, non-pharmaceutic wound dressings that provide excellent biocompatibility and enhanced tissue regeneration in both acute and chronic wound healing.

Indexed as

biocompatibilityhydrogelnatural therapeutic extractssynergisticwound healing

Identifiers

PMID41374792
PMCPMC12693776

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.