Evidence map›Paper›PMID 41375019›Full record

ArticleCancers2025

Targeting CXCR6 Disrupts β-Catenin Signaling and Enhances Sorafenib Response in Hepatocellular Carcinoma.

Morgan Reeves, Anastasia Chambers, Abhishek Shrestha, Sergio Duarte, Ali Zarrinpar, Siobhan Malany, Satyamaheshwar Peddibhotla

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Morgan ReevesDepartment of Cellular and Systems Pharmacology, University of Florida College of Pharmacy, 1225 Center Drive, Gainesville, FL 32610, USA.
Anastasia ChambersDepartment of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610, USA.ORCID 0009-0003-3939-3569
Abhishek ShresthaDepartment of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610, USA.ORCID 0000-0003-1576-8584
Sergio DuarteDepartment of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610, USA.
Ali ZarrinparDepartment of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610, USA.
Siobhan MalanyDepartment of Cellular and Systems Pharmacology, University of Florida College of Pharmacy, 1225 Center Drive, Gainesville, FL 32610, USA.ORCID 0000-0003-0710-7460
Satyamaheshwar PeddibhotlaDepartment of Cellular and Systems Pharmacology, University of Florida College of Pharmacy, 1225 Center Drive, Gainesville, FL 32610, USA.

Funding

Advancing small molecule CXCR4 agonists for diabetic wound healingR01DK126371 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LIECHTY, KENNETH W, MALANY, SIOBHAN · 2020 to 2024
$2.6M
Utilization of Phenotypic Precision Medicine to Identify Optimal Drug Combinations for the Treatment of Hepatocellular CarcinomaUH2TR002087 · NCATS · UNIVERSITY OF FLORIDA · PI HO, CHIH-MING, ZARRINPAR, ALI · 2017 to 2018
$556k
Preclinical development of CXCR6 antagonists to target sorafenib resistance in Hepatocellular CarcinomaR21CA270714 · NCI · UNIVERSITY OF FLORIDA · PI MALANY, SIOBHAN, PEDDIBHOTLA, SATYAMAHESHWAR · 2022 to 2023
$388k
NCI NIH HHS R21CA270714NIDDK NIH HHS R01DK126371NIH/NCATS UH2TR002087UF Research DRPD-ROSF2022
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CXCL16CXCR6CXCR6 antagonisthepatocellular carcinomaprecision oncologySBI457sorafenib resistancetargeted therapytumor microenvironmentβ-catenin

Identifiers

PMID41375019
PMCPMC12691426

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.