From Lipid Regulation to Neuroprotection: Multitarget (Benzo)thiazine Derivatives as Promising Leads.

Ariadni Tzara, Andrea Andreou, Angeliki P Kourounakis

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Long-Chain Fatty Acids as Drivers of Neuroinflammation in Neurodegeneration: Mechanistic Links to Lipid Peroxidation, Ferroptosis, and Mitochondrial Dysfunction.Nutrients · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ariadni TzaraDepartment of Medicinal Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece.

Andrea AndreouDepartment of Medicinal Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece.

Angeliki P KourounakisDepartment of Medicinal Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative and cardiovascular disorders share multifactorial origins, including oxidative stress, (neuro)inflammation, and lipid dysregulation-factors often addressed independently by single-target therapies. In this study, we report a rational multitarget approach through the design and synthesis of novel (benzo)thiazine derivatives that integrate antioxidant, anti-inflammatory, and antihyperlipidemic functionalities within a single molecular framework. The compounds were obtained in good yields via 3-7 step synthetic routes and evaluated through complementary in vitro and in vivo assays. Several derivatives displayed potent inhibition of lipoxygenase (IC

Indexed as

Lipid MetabolismNeuroprotectionNeuroprotective AgentsThiazinesAnimalsAnti-Inflammatory AgentsAntioxidantsEdemaLipid PeroxidationLipoxygenase InhibitorsMiceOxidative StressAnti-Inflammatory AgentsAntioxidantsLipoxygenase InhibitorsNeuroprotective AgentsThiazinesanti-hyperlipidemicanti-inflammatoryantioxidantcardiovascularmultitargetneurodegenerationneuroinflammation

Identifiers

PMID41375139

DOI10.3390/molecules30234542

PMCPMC12693416

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.