Evidence map›Paper›PMID 41375183›Full record

ArticleMolecules (Basel, Switzerland)2025

Biotin-Linked Ursolic Acid Conjugates as Selective Anticancer Agents and Target-Identification Tools for Cancer Therapy.

Riham M Bokhtia, Kunj Bihari Gupta, Annabella Natalini, Theerth Vikas Srinivasan, Nihal Amineni, Sophia Ying, Rajeev Shakuja, Guido F Verbeck, Bal L Lokeshwar, Siva S Panda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riham M BokhtiaDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0001-5326-7364
Kunj Bihari GuptaGeorgia Cancer Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-5017-7192
Annabella NataliniDepartment of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.
Theerth Vikas SrinivasanDepartment of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0007-2809-5610
Nihal AmineniDepartment of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.
Sophia YingDepartment of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0000-7613-7917
Rajeev ShakujaDepartment of Chemistry, University of Delhi, New Delhi, Delhi 110007, India.
Guido F VerbeckDepartment of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-3317-9911
Bal L LokeshwarGeorgia Cancer Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1763-4718
Siva S PandaDepartment of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.

Funding

United States Department of Defense HT94252310761
6 · The paper itself

Abstract

Ursolic acid (UA), a naturally occurring pentacyclic triterpenoid, exhibits potent anticancer properties; however, its poor solubility and bioavailability limit its therapeutic application. To overcome these challenges and facilitate molecular target identification, a set of biotin-conjugated UA derivatives (

Indexed as

Antineoplastic AgentsBiotinNeoplasmsTriterpenesApoptosisCell Line, TumorCell ProliferationHumansReactive Oxygen SpeciesUrsolic AcidAntineoplastic AgentsBiotinReactive Oxygen SpeciesTriterpenesUrsolic Acidanticancer agentsbioconjugatebiotinin vitro assaysmicrowave-assisted synthesisnatural productproteomicsselectivity indexUrsolic acid

Identifiers

PMID41375183
PMCPMC12692861

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.